Results 51 to 60 of about 367,469 (248)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Instruction Sequences with Dynamically Instantiated Instructions [PDF]

Fundamenta Informaticae, 2009
We study sequential programs that are instruction sequences with dynamically instantiated instructions. We define the meaning of such programs in two different ways. In either case, we give a translation by which each program with dynamically instantiated instructions is turned into a program without them that exhibits on execution the same behaviour ...
Bergstra, J.A., Middelburg, C.A.
openaire   +4 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Erdheim-Chester disease: a rare histiocytosis (case report and review of the literature)

The Pan African Medical Journal, 2018
We report a case of Erdheim-chester disease, a rare non-langerhans histiocytosis revealed by polydipsia-polyuria syndrome in a 26 years old woman, trated by interferon with a good response.
Mahtat El Mehdi, Safae Regragui, Hicham Eddou, Selim Jennane, Hicham El Maaroufi, Kamal Doghmi, Mohamed Mikdame   +6 more
doaj   +1 more source

Les résultats de la technique de Latarjet dans l´instabilité antérieur de l´épaule en fonction de la position radiologique de la butée coracoïdienne

The Pan African Medical Journal, 2021
L´instabilité antérieure de l´épaule suite à une luxation traumatique chez l´adulte jeune est une complication fréquente. La procédure de Latarjet est la technique la plus utilisée pour traiter cette instabilité, consiste à réaliser une butée ...
Oueslati Achraf, Rafrafi Abderrazzek, Znagui Talel, Saadi Saber, Nouisri Lotfi   +4 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Maladie de Still de l´adulte et lymphome: une association rare

The Pan African Medical Journal, 2020
La maladie de Still de l´adulte (MSA) et les lymphomes sont des pathologies dont la présentation clinique et même histopathologique est très proche. L′association des deux pathologies est rarement rapportée dans la littérature.
Jihane Smaali, Abdessadak El Khattabi, Mohamed El Qatni, Fadoua Mekouar, Youssef Sekkach, Ali Abouzahir, Taoufik Ameziane, Driss Ghafir   +7 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source