Results 81 to 90 of about 903,001 (251)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Pre-service teachers’ metaphors of the relationship between curriculum and instruction: Relationship between curriculum and instruction

, 2022
This study analyzed pre-service teachers’ metaphors of the relationship between curriculum and instruction. On analysis, results revealed that PRESETs use diverse metaphors that are related to their everyday lived experiences.
Kareem, Adeyinka Oluwaseun, Oyetoro, Oyebode   +1 more
core   +1 more source

‘We mean more than what we say on air’: interactional metadiscourse resources in television talk shows

Cogent Social Sciences
This study explores the interactional metadiscourse resources employed on a Ghanaian television talk show and the communicative functions of these resources in persuading the target audience of the show. Five episodes of the television talk show prior to
Emmanuel Nii Adama Mensah, Christiana Hammond, Albert Agbesi Wornyo   +2 more
doaj   +1 more source

Chinese Pioneering Educators’ Understandings and Practices of STEM Education [PDF]

Journal of Research in Science, Mathematics and Technology Education
The Chinese education system issued a series of policies to encourage educators to explore science, technology, engineering, and mathematics (STEM) education and selected a number of schools and educators as pioneers of STEM education.
Qiu Zhong, Conghui Liu, Adam Vincent Maltese, Jing Yang   +3 more
doaj   +1 more source

Les fractures de la palette humérale : a propos de 45 cas

PAMJ Clinical Medicine, 2020
Les fractures de la palette humérale, apanage de l´adulte jeune, sont le plus souvent complexes, en rapport avec la violence et l´augmentation des accidents de la voie publique.
Mohamed Reda Ouzaa, Azzelarab Bennis, Omar Zaddouk, Ali Zine, Mansour Tanane, Mohamed Benchakroun, Abdeloiahab Jaafar   +4 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The Effects of Schema-Based Instruction on Word-Problems in a ThirdGrade Mathematics Classroom

, 2023
In this study we tested the effects of schema-based instruction (SBI) strategies on 3 rd grade students’ mathematics skills. We compared SBI to general strategy instruction (GSI) when teaching multi-step word problems to students in mixedabilities ...
Skinner, Mallory G., Cuevas , Joshua A.
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source