Results 31 to 40 of about 35,080 (219)

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Chinese teachers’ perspectives on opportunities and challenges of immersive virtual reality technology in higher art education

Discover Education
The application of virtual reality (VR) technology in higher arts education offers novel pedagogical approaches aims at enhancing students' learning experiences and comprehension.
Shi Yue, Mageswaran Sanmugam, Yao Hanben
doaj   +1 more source

The Impact of Health Status, Chronic Conditions, and Mental Fatigue on College Students’ Grade Expectations in Online Courses

European Journal of Investigation in Health, Psychology and Education
This study explores the impact of mental fatigue, health status, and chronic conditions on college students’ grade expectations in online courses. Data were gathered from 418 undergraduate students through an online survey assessing mental fatigue and ...
Fethi Ahmet Inan, Deniz Unal, Fatemeh Marzban, Edwin Teye Sosi, Gail Alleyne Bayne   +4 more
doaj   +1 more source

Technology Matters – The Impact of Transactional Distance on Satisfaction in Online Distance Learning

International Review of Research in Open and Distributed Learning, 2018
Transactional distance (TD), the perception of psychological distance between the student and his peers, his instructor/teacher, and the learning content, has long been a prominent construct in research on distance education.
Joshua Weidlich, Theo J. Bastiaens
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Evaluating augmented reality in physical education for dyslexic students from the perspectives of teachers and students

Scientific Reports
Students with dyslexia (SWDs), which is a specific learning problem that impairs reading, often experience inadequate academic performance and have a negative perception of themselves in general.
Nur Azlina Mohamed Mokmin, Regania Pasca Rassy, Darren Lim Yie   +2 more
doaj   +1 more source

An investigation of faculty perspectives on barriers, incentives, and benefits of the OER movement in Turkey

International Review of Research in Open and Distributed Learning, 2014
The purpose of this survey study is to investigate faculty’s perceptions of the main incentives, barriers, and benefits to publishing their course materials for free within the open educational resources (OER) movement. Data were collected from an online
Engin Kursun, Kursat Cagiltay, Gulfidan Can   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Optimizing cognitive load and learning adaptability with adaptive microlearning for in-service personnel

Scientific Reports
Adaptive microlearning has emerged as a crucial approach for enhancing the working skills of in-service personnel. This study introduces the design and development of an innovative adaptive microlearning (AML) system and investigates its effectiveness ...
Bo Zhu, Kien Tsong Chau, Nur Azlina Mohamed Mokmin   +2 more
doaj   +1 more source