Results 51 to 60 of about 35,080 (219)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
以翻轉式概念構圖提升學生閱讀理解能力之研究 The Flip Concept Map in Relation to Student’s Reading Comprehension Skills
Journal of Curriculum Studies, 2016 本研究以翻轉式概念構圖為教學策略，期望能提升學生的閱讀理解能力。研究對象為新北市某國小五年級學生，以立意取樣選取兩個班級作為實驗組及控制組，實驗組教師運用翻轉式概念構圖進行教學，控制組教師以傳統講述式進行大意教學。本研究採準實驗研究設計，歷時10週，共10堂課（400分鐘），研究結果發現，實驗組經由翻轉式概念構圖的教學，在「提取訊息」與「推論訊息」沒有顯著差異，但在「詮釋整合」與「比較評估」的能力明顯優於控制組，且實驗組之中的高學習成效學生經過實驗後，在「推論訊息」能力上與低學習成效學生沒有顯著差異 ...
吳佳娣 Chia-Ti Wu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
INSTRUCTİONAL TECHNOLOGY & TECHNOLOGİST
Sakarya Üniversitesi Eğitim Fakültesi Dergisi, 2014 .
Emre Bütün, Meryem Şen, Refik Şanlı
doaj
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Informatics in Education, 2018 Despite a growing effort to implement computational thinking (CT) skills in primary schools, little research is reported about what CT skills to teach at what age.
Wouter J. RIJKE +3 more
doaj +1 more source
Use of Cognitive Load Theory to Deploy Instructional Technology for Undergraduate Medical Education: a Scoping Review. [PDF]
Med Sci Educ, 2022 Hochstrasser K, Stoddard HA.
europepmc +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source