Results 141 to 150 of about 2,342,791 (305)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Instructions for Authors

, 2014
Authors, Instructions for
core   +1 more source

Submission instructions for [2008]: Visiting Fellows, Center for Philosophy of Science (2008-2009, Pittsburgh)

, 2009
Submission instructions for [2008]: Visiting Fellows, Center for Philosophy of Science (2008-2009, Pittsburgh)
Instructions, Submission
core  

Caregiver Perspectives on Implementation of Discharge Plans for Children With Medical Complexity. [PDF]

Hosp Pediatr
Glick AF, Landon S, Tirado FM, Yin HS, Vaydie Silveiro L, Farkas JS, Goodwin EJ, Modi AC, Piotrowski K, Clementi E, Dickson VV.   +10 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Submission instructions for [2009] Thought Experiments: A Workshop (Toronto, May 22-23, 2009)

, 2009
Submission instructions for [2009] Thought Experiments: A Workshop (Toronto, May 22-23, 2009)
Instructions, Submission
core  

Autistic and non-autistic children's perceptual decision-making in visual orientation and motion tasks and the effect of task instructions. [PDF]

Atten Percept Psychophys
Thomas L, Scerif G, Yusuf H, Laird M, Taylor G, Evans NJ, Manning C.   +6 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Submission instructions for [2008] Philosophy of Science Assoc. 21st Biennial Mtg (Pittsburgh, PA)

, 2008
Submission instructions for [2008] Philosophy of Science Assoc.
Instructions, Submission
core  

Acute Effects of External, Internal, and Holistic Attentional Focus on Javelin-Throwing Performance in Novices: The Role of Visual Information. [PDF]

J Funct Morphol Kinesiol
Asadi A, Bahrami S, Bahrami M, Saemi E.
europepmc   +1 more source