Results 51 to 60 of about 28,623 (152)

An analysis of Space Shuttle countdown activities: Preliminaries to a computational model of the NASA Test Director [PDF]

Before all systems are go just prior to the launch of a space shuttle, thousands of operations and tests have been performed to ensure that all shuttle and support subsystems are operational and ready for launch.
John, Bonnie E., Remington, Roger W., Steier, David M.   +2 more
core   +1 more source

3′UTR variants of ALS‐linked RNAs modify subcellular and cellular phenotypes

The FEBS Journal, EarlyView.
Our study demonstrates that alternative 3′UTR variants of ALS‐linked transcripts modulate subcellular RNA localization and cytoskeletal architecture. NEFH 3′UTR‐Long promotes nuclear RNA clustering, while SOD1 3′UTR‐Long reduces filopodia formation. These results suggest that 3′UTRs, independent of coding sequences, can influence neuronal phenotypes ...
Melis Savasan‐Sogut, Danae Campos‐Melo, Michael J. Strong   +2 more
wiley   +1 more source

Constraint-based scheduling [PDF]

The GERRY scheduling system developed by NASA Ames with assistance from the Lockheed Space Operations Company, and the Lockheed Artificial Intelligence Center, uses a method called constraint based iterative repair. Using this technique, one encodes both
Zweben, Monte
core   +1 more source

Cognitive performance is related to central sensitization and health-related quality of life in patients with chronic whiplash-associated disorders and fibromyalgia [PDF]

, 2015
Background: A growing body of research has demonstrated that impaired central pain modulation or central sensitization (CS) is a crucial mechanism for the development of persistent pain in chronic whiplash-associated disorders (WAD) and fibromyalgia (FM)
Cagnie, Barbara, Coppieters, Iris, De Pauw, Robby, Ickmans, Kelly, Meeus, Mira, Nijs, Jo, Noten, Suzie   +6 more
core  

The Dual Immunoregulatory Role of CREB3L1 Underlying Latent and Severe Tuberculosis Clinical Manifestation

Immunology, EarlyView.
RNA‐seq of lungs and livers from Mycobacterium tuberculosis‐infected mice with distinct disease outcomes revealed organ‐specific responses driven by differences in immune activity and bacterial burden. Meta‐analysis identified orthologous genes shared with human latent TB and mouse liver, with Creb3l1, Myo7b, Cyyr1 and Cbs differentially expressed and ...
Felipe T. Lima, Ricardo C. Castro, Francisco R. Javier, Caroline Fontanari, Valdes R. Bollela, Rogerio S. Rosada, Célio L. Silva, Lúcia H. Faccioli, Luiz G. Gardinassi, Fabiani G. Frantz   +9 more
wiley   +1 more source

Building a Digital Health Innovation Ecosystem: Tech‐Push, Demand‐Pull, and Government Policy

Information Systems Journal, EarlyView.
ABSTRACT Health and social care are at a pivotal point, encountering complex and multifaceted systemic and workforce‐related challenges. Governments have identified the need to redefine health and social care services to address the evolving needs of both patients and service providers.
Denis Dennehy, Thomas James, Daniel Rees, Roderick Thomas, M. N. Ravishankar   +4 more
wiley   +1 more source

Joint effects of elevated copper and temperature in juvenile Tambaqui exposed in black and white waters of the Amazon

Journal of Fish Biology, EarlyView.
Abstract This study aimed to investigate how exposure to elevated water temperature and metal concentration jointly affect the physiology of Amazonian fish. Aboard a research vessel in the Amazon, we evaluated the effects of water temperature (river T°C at 31.5°C and a + 4°C increase to 35.5°C) and of 3‐h copper (Cu) exposure (up to 600 μg/L) in ...
Anne Crémazy, Carolyn Morris, Susana Braz‐Mota, Chris M. Wood, Rafael M. Duarte, Ora E. Johannsson, Adalberto L. Val   +6 more
wiley   +1 more source

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy. [PDF]

, 2019
Ovarian cancer and triple-negative breast cancer are among the most lethal diseases affecting women, with few targeted therapies and high rates of metastasis. Cancer cells are capable of evading clearance by macrophages through the overexpression of anti-
Barkal, Amira A, Barkal, Layla J, Barkal, Sammy A, Brewer, Rachel E, Dorigo, Oliver, Hatakeyama, Jason, Kowarsky, Mark, Krishnan, Venkatesh, Markovic, Maxim, Weissman, Irving L, Zaro, Balyn W   +10 more
core  

Guiding Midwives to Precept Students: Two Evidence‐Based Models

Journal of Midwifery &Women's Health, EarlyView.
Abstract The success of midwifery education relies heavily on the time and expertise shared by experienced midwifery preceptors. Although there are several known and documented barriers to preceptor availability and willingness to participate in the education of future midwives, clinical education opportunities are crucial to midwifery education ...
Margaret C. Taylor, Hannah L. Diaz
wiley   +1 more source

ANALYSIS, MANAGEMENT AND TRADE-OFF WITH RISKS OF TECHNICAL FACILITIES [PDF]

, 2020
Submitted work “Analysis, management and trade-off with risk of technical facilities“ deals with the all type of risks associated with the technical facilities, particularly with the complex ones, with aim to ensure their safety. It demonstrates the ways
Procházka J., Procházková D.
core