Results 171 to 180 of about 3,500,243 (336)
Development of the Temporal Intelligence Questionnaire. [PDF]
Research has demonstrated that the temporal characteristics of individuals and jobs significantly predict outcome variables such as well-being and performance (Francis-Smythe & Robertson, 2003; Hecht & Allen, 2003; Slocombe & Bluedorn; 1999). This paper
Doyle, Andrew, Francis-Smythe, Jan
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Ill-Health as a Household Norm: Evidence from Other People's Health Problems [PDF]
This paper presents evidence that an individual's self-assessed health (SAH) does not only suffer from systematic reporting bias and adaptation bias but is also biased owing to confounding social norm effects.
N Powdthavee
core
Afromaison. Project objective, work progress and achievements project management : Core part of the mid-term report [PDF]
, 2012 Natural resources are essential for maintaining or improving people's livelihood, especially in Africa. Integrated management of natural resources (INRM) is a way to maintain ecosystems capacity to produce a broad range of goods and services considering ...
D'Haeyer, Tom +2 more
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
STR: a student developed star tracker for the ESA-LED ESMO moon mission [PDF]
, 2010 In the frame of their engineering degree, ISAE’s students are developing a Star Tracker, with the aim of being the core attitude estimation equipment of the European Moon Student Orbiter.
Lizy-Destrez, Stéphanie, Mimoun, David
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Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source