Results 81 to 90 of about 129,371 (267)

A NEW INSTRUMENT FOR THE CLINICAL MEASUREMENT OF DARK ADAPTATION [PDF]

Journal of the American Medical Association, 1916
The measurement of the dark adaptation of the eye has usually been confined to laboratory observers because of the time such an examination requires and because of the complexity of the instruments used. Consequently, valuable clinical information has frequently been over-looked.
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Transcultural adaptation into Portuguese of an instrument for pain evaluation based on the biopsychosocial model

Fisioterapia em Movimento
Introduction: Pain is an individual experience influenced by multiple interacting factors. The “biopsychosocial” care model has gained popularity in response to growing research evidence indicating the influence of biological, psychological, and social ...
Monique Rocha Peixoto dos Santos, Leandro Calazans Nogueira, Ney Armando Meziat-Filho, Rob Oostendorp, Felipe José Jandre dos Reis   +4 more
doaj   +1 more source

Cross-cultural adaptation of the Spence Children's Anxiety Scale in Malaysia

Trends in Psychiatry and Psychotherapy, 2015
Introduction: Anxiety among children has increased in recent years. Culturally adapted questionnaires developed to measure the level of anxiety are the best screening instruments for the general population. This study describes the scientific translation
Atefeh Ahmadi, Mohamed Sharif Mustaffa, AliAkbar Haghdoost, Aqeel Khan, Adibah Abdul Latif   +4 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Implementing the TRAPD model for the Saudi adaptation of the World Mental Health Composite International Diagnostic Interview 3.0

International Journal of Mental Health Systems, 2019
Background The World Mental Health-Composite International Diagnostic Interview (CIDI) 3.0, originally in English, is a fully-structured interview designed for the assessment of mental disorders.
Mona Shahab, Feda Al‐Tuwaijri, Noha Kattan, Lisa Bilal, Sanaa Hyder, Zeina Mneimneh, Yu-chieh Lin, AbdulHameed Al-Habeeb, Abdullah Al-Subaie, Abdulrahman Binmuammar, Yasmin Altwaijri   +10 more
doaj   +1 more source

Perceptions and knowledge of telemedicine in Ecuadorian practicing physicians: an instrument adaptation, validation and translation from English to Spanish. [PDF]

BMC Public Health, 2021
Alvarado-Villa G, KuonYeng-Escalante C, Sagñay-Pinilla N, Vera Paz C, Cherrez-Ojeda I.   +4 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Personality Inventory for DSM-5 (PID-5): cross-cultural adaptation and content validity in the Brazilian context

Trends in Psychiatry and Psychotherapy
Objective To describe the process of cross-cultural adaptation of the Personality Inventory for DSM-5 (PID-5) to the Brazilian context. Methods Cross-cultural adaptation involved the steps of independent translation of the instrument, synthesis ...
Ana Maria Barchi-Ferreira, Sonia Regina Loureiro, Albina Rodrigues Torres, Thiago Dornela Apolinário da Silva, André Luiz Moreno, Diogo Araújo DeSousa, Marcos Hortes Nisihara Chagas, Rafael Guimarães dos Santos, João Paulo Machado-de-Souza, Natália Mota de Sousa Chagas, Jaime Eduardo C. Hallak, José Alexandre de Souza Crippa, Flávia L. Osório   +12 more
doaj   +1 more source