Results 91 to 100 of about 491,831 (312)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
A Mode Matched Triaxial Vibratory Wheel Gyroscope with Fully Decoupled Structure
Sensors, 2015 To avoid the oscillation of four unequal masses seen in previous triaxial linear gyroscopes, a modified silicon triaxial gyroscope with a rotary wheel is presented in this paper.
Dunzhu Xia, Lun Kong, Haiyu Gao
doaj +1 more source
Private education provision and public finance : the Netherlands [PDF]
One of the key features of the Dutch education system is freedom of education -- freedom to establish schools and organize teaching. Almost 70 percent of schools in the Netherlands are administered by private school boards, and all schools are government
Patrinos, Harry Anthony
core
The dimensions of approaches to teaching in higher education: a new analysis of teaching profiles [PDF]
The exploration of higher education (HE) teachers’ approaches to teaching has mainly been done using quantitative instruments which have been criticised for being too narrow in examining the dimensions of teaching. Higher education approaches to teaching
Parpala Anna +3 more
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
A Hybrid Approach Based on Improved AR Model and MAA for INS/DVL Integrated Navigation Systems
IEEE Access, 2019 In navigation of autonomous underwater vehicles (AUVs), the estimation of position is an important issue, especially, when the sensors such as gyroscopes contain a lot of noise, and the velocity information of Doppler velocity log (DVL) is affected by ...
Di Wang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Advanced Instrumentation in the Educational Laboratory [PDF]
Journal of Chemical Education, 1996 The instruments that chemists use in their research have changed dramatically in the past decades. The explosion in new techniques and their instrumental counterparts has been made possible by two significant advances.
openaire +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
, 2017 The purpose of this study was to determine the impact of environmental factors in disadvantaged communities on misdiagnosis or a lack of a diagnosis, and the implications of pre-referral and Response to Interventions (RTI) on student identification for ...
Dowding, John C.
core +1 more source