Results 101 to 110 of about 491,831 (312)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Instrumentation in Mathematics Education [PDF]

, 2014
In order to define instrumentation in the context of mathematics education, it is necessary to define instruments: at this stage of this article, we do not differentiate between instruments and artifacts, i.e., we regard them as things that are created and used by humans to help, assist, support, enlarge, and empower their activity.
openaire   +1 more source

An instrument for evaluating vocational education in Israel

, 1984
The purpose of this study was to construct an instrument which would enable administrators and teachers to evaluate selected parts of vocational education programs in post-primary schools in Israel.
Friedler, Arieh Kalman
core  

Representing contextual mathematical problems in descriptive or depictive form: Design of an instrument and validation of its uses [PDF]

, 2016
The aim of this study is to contribute to the body of knowledge on the use of contextual mathematical problems. Word problems are a predominant genre in mathematics classrooms in assessing students’ ability to solve problems from everyday life.
Gravemeijer, K.P.E., Bakker, Arthur, Gravemeijer, Koeno, Gravemeijer, K. (Koeno), Pepin, B.E.U., Sub Mathematics Education, Pepin, BEU Birgit, Gravemeijer, KPE Koeno, Hoogland, C.P., Pepin, Birgit, Pepin, B. (Birgit), Hoogland, K. (Kees), Koning, Jaap de, Koning, J. (Jaap) de, Hoogland, Kees, Mathematics Education, Bakker, A. (Arthur), Hoogland, CP Kees, Koning,de, Jaap, de Koning, Jaap   +19 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

RG 8005.015 Board of Education Photograph Collection

, 2012
Unidentified class playing with musical ...
Delaware Board of Education
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

An Intelligent System for Outfall Detection in UAV Images Using Lightweight Convolutional Vision Transformer Network

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Unmanned aerial vehicle aerial photography technology has become a crucial tool for detecting outfalls that discharge into rivers and oceans. However, the current retrieval process in aerial images relies heavily on visual interpretation by skilled ...
Mingxin Yu, Ji Zhang, Lianqing Zhu, Shengjun Liang, Wenshuai Lu, Xinglong Ji   +5 more
doaj   +1 more source