Results 121 to 130 of about 418,975 (381)

The Instrumental Activity of Daily Living Profile in Aging: A Feasibility Study

Journal of Alzheimer's Disease, 2016
Dysfunctions in complex activities of daily living (ADLs) are a normal part of the aging process. However, differentiating functional decline associated with healthy aging from the subtle decline experienced by individuals with mild cognitive impairment and early dementia constitutes a challenge.
Mioshi, Eneida, Bier, Nathalie, da Cunha Belchior, Patricia, Paquette, Guillaume Paquette, Beauchemin, Emilie, Lacasse-Champagne, Ariane, Messier, Chantal, Pellerin, Marie-Line, Petit, Marisol, Bottari, Carolina   +9 more
openaire   +5 more sources

Is function in instrumental activities of daily living a useful feature in predicting Alzheimer's disease dementia in subjective cognitive decline?

International Journal of Geriatric Psychiatry, 2018
Subjective cognitive decline (SCD), the earliest symptom in preclinical Alzheimer's disease (AD), is insufficient to identify individuals at risk for AD dementia.
S. Roehr, S. Riedel-Heller, H. Kaduszkiewicz, M. Wagner, A. Fuchs, Carolin van der Leeden, B. Wiese, J. Werle, H. Bickel, H. König, S. Wolfsgruber, M. Pentzek, D. Weeg, S. Mamone, S. Weyerer, C. Brettschneider, W. Maier, M. Scherer, F. Jessen, T. Luck   +19 more
semanticscholar   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Age and gender differences in the association between social participation and instrumental activities of daily living among community-dwelling elderly

BMC Geriatrics, 2017
BackgroundAlthough many studies have suggested social participation (SP) has beneficial effects on elderly people’s health, most of them failed to deal with paid work. Additionally, few studies have focused on the age effect between SP and older people’s
K. Tomioka, N. Kurumatani, H. Hosoi
semanticscholar   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Early diagnosis of mild cognitive impairment and mild dementia through basic and instrumental activities of daily living: Development of a new evaluation tool

PLoS Medicine, 2017
Background Assessment of activities of daily living (ADL) is paramount to determine impairment in everyday functioning and to ensure accurate early diagnosis of neurocognitive disorders.
E. Cornelis, E. Gorus, I. Beyer, I. Bautmans, Patricia de Vriendt   +4 more
semanticscholar   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Self-Perception of Aging and Vulnerability to Adverse Outcomes at the Age of 65-70 Years [PDF]

, 2017
Objectives. This study examines the relationship between self-perception of aging and vulnerability to adverse outcomes in adults aged 65-70 years using data from a cohort of 1,422 participants in Lausanne, Switzerland. Methods.
Moser, Charlotte, Santos-Eggimann, Brigitte, Spagnoli, Jacques   +2 more
core  

Association between fulfilling the recommendations for health-enhancing physical activity with (instrumental) activities of daily living in older Austrians

Wiener Klinische Wochenschrift, 2019
SummaryAimThe aim of the study was to describe the association between fulfilling the recommendation for health-enhancing physical activity (PA), and deficits in activities of daily living (ADL) and instrumental activities of daily living (IADL) in 3308 ...
R. Crevenna, T. Dorner
semanticscholar   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source