Results 101 to 110 of about 437,497 (311)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Evaluating Driving as a Valued Instrumental Activity of Daily Living

The American Journal of Occupational Therapy, 2011
Abstract The purpose of this translational research article is to illustrate how general practice occupational therapists have the skills and knowledge to address driving as a valued occupation using an algorithm based on the Occupational Therapy Practice Framework: Domain and Process (2nd ed.; American Occupational Therapy Association ...
Dickerson, Anne E., Reistetter, Timothy, Davis, Elin Schold, Monahan, Miriam   +3 more
openaire   +4 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Recognition of activities of daily living in natural “at home” scenario for assessment of Alzheimer's disease patients [PDF]

, 2015
In this paper we tackle the problem of Instrumental Activities of Daily Living (IADLs) recognition from wearable videos in a Home Clinical scenario. The aim of this research is to provide an accessible and yet detailed video-based navigation interface of
Benois-Pineau, Jenny, Buso, Vincent, Hopper, Louise, Megret, Remi, Plans, Pierre-Marie   +4 more
core   +3 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Proposal for a revised Barthel index classification based on mortality risk assessment in functional dependence for basic activities of daily living

Frontiers in Public Health
IntroductionFunctional dependence on the performance of basic activities of daily living (ADLs) is associated with increased mortality. In this study, the Barthel index and its activities discriminate long-term mortality risk, and whether changes in this
Vicente Martín Moreno, Vicente Martín Moreno, María Inmaculada Martínez Sanz, Amanda Martín Fernández, Sara Guerra Maroto, Eva Sevillano Fuentes, Elena Pérez Rico, Irene Sánchez González, Miriam Fernández Gallardo, Julia Herranz Hernando, María Palma Benítez Calderón, Laura Calderón Jiménez, Elena Sánchez Rodríguez, Miguel Recuero Vázquez, Helena Alonso Samperiz, Irene León Saiz, Juana Marcos Guerra   +16 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The impact of a residential fire on occupational engagement and performance: A reflexive narrative approach

Burns Open
Residential fires are a devastating and stressful life event. The high number of residential fires per year and significant associated stressors impacts all aspects of daily life.
Gregory Chown
doaj   +1 more source

Disabilty in Older Adults with Depression [PDF]

, 2005
Depression is a leading cause of disability among older adults which can change the scope of daily life for older adults and threaten their ability to live independently in the community.
Chisholm, Denise
core  

Sensitivity of the Mini-Mental State Examination, Montreal Cognitive Assessment and the Addenbrooke’s Cognitive Examination III to everyday activity impairments in dementia: An exploratory study [PDF]

, 2016
Objective: The Mini-Mental State Examination (MMSE) is one of the most frequently used cognitive measures for dementia severity, and linked to deficits in everyday functioning.
Challis, David, Giebel, Clarissa M.
core   +2 more sources