Results 81 to 90 of about 166,808,572 (290)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Effect of Chronic Noncommunicable Diseases Multimorbidity on Functional Disability in Older Adults in Ireland: Evidence From the 2019 Irish Health Survey

Chronic Diseases and Translational Medicine
Background Understanding how multimorbidity affects activities of daily living (ADL) and instrumental activities of daily living (IADL) disability in older Irish adults is essential for planning responsive health and social care systems that can support ...
Alwalid Ali, Santosh Sharma
doaj   +1 more source

The Relationship between Chronic Diseases and Disability in Daily Activities and Instrumental Activities of Daily Living in the Elderly [PDF]

, 2018
BACKGROUND AND OBJECTIVE: Chronic disease is one of the major causes of disability in doing daily activities. The aim of this study is to determine the relationship between chronic disease and disability in daily activities and instrumental activities of
A Zabihi, SR Hosseini, A Bijani, Zabihi, A, JafarianAmiri, SR, Hosseini, SR, SR Jafarian Amiri, Bijani, A   +7 more
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Reliability and Responsiveness of the Activities of Daily Living Computerized Adaptive Testing System in Patients With Stroke

, 2017
Objective: To examine the intrarater reliability, interrater reliability, and responsiveness of the Activities of Daily Living Computerized Adaptive Testing system (ADL CAT) in patients with stroke.
Lee, Ya-Chen;Yu, Wan-Hui;Lin, Yu-Fen;Hsueh, I-Ping;Wu, Hung-Chia;Hsieh, Ching-Lin, ������;�²M��   +1 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Association between nutrition literacy and physical function limitations among geriatric population in China

BMC Geriatrics
Introduction To assess the relationship between nutrition literacy (NL) and physical function limitations among Chinese older adults. Methods It was a cross-sectional survey carried out in May–July 2023, in Bengbu, China.
Yuhui Sun, Xi Tian, Xiaoting Hu, Huaqing Liu   +3 more
doaj   +1 more source

Prevalence of activities of daily living and instrumental activities of daily living limitations at five years of follow up for participants with chronic diseases at baseline.

, 2020
Prevalence of activities of daily living and instrumental activities of daily living limitations at five years of follow up for participants with chronic diseases at baseline.
Edwin van den Heuvel (163336), Nazmul Sohel (23199), Parminder Raina (2272063), Anne Gilsing (8474058), Alexandra J. Mayhew (8474061), Lauren E. Griffith (3338394)   +5 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Performance-based Tools for Assessing Functional Performance in Individuals with Mild Cognitive Impairment

Open Journal of Occupational Therapy, 2015
Background: It is now recognized that individuals with mild cognitive impairment (MCI) face subtle functional declines that can compromise performance in everyday tasks.
Patrícia Belchior, Melanie Holmes, Nathalie Bier, Carolina Bottari, Barbara Mazer, Alexandra Robert, Navaldeep Kaur   +6 more
doaj   +1 more source