Results 61 to 70 of about 437,497 (311)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Effect of Cognitive Training on Daily Function in Older People without Major Neurocognitive Disorder: A Systematic Review

Geriatrics, 2019
There is increasing interest in the effect of non-pharmacological treatments on preserving cognition and function in older adults without major neurocognitive disorder (dementia).
Brian J.Y. Fan, Roger Y.M. Wong
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Accomplishment of instrumental activities of daily living and its relationship with cognitive functions in adults with myotonic dystrophy type 1 childhood phenotype: an exploratory study

BMC Psychology, 2021
Background The childhood phenotype of myotonic dystrophy type 1 (DM1) involves impaired cognitive functioning starting in infancy, which may compromise later on their ability to carry out instrumental activities of daily living (IADLs) necessary for ...
Marjolaine Tremblay, Samar Muslemani, Isabelle Côté, Cynthia Gagnon, Julie Fortin, Benjamin Gallais   +5 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Evaluation of activities and instrumental activities of daily living and correlated factors of traumatic brain injury patients in Vietnam

Scientific Reports
Traumatic brain injury (TBI) is among the leading causes of death in Vietnam. Survivors of TBI suffer from functional and cognitive deficits. Understanding that Activities of Daily Living (ADLs) and Instrumental Activities of Daily Living (IADLs) are ...
Anh Thuy Hoang, Tung Hoang Tran, Hai Minh Vu, Hoa Thi Do, Thuc Minh Thi Vu, Linh Gia Vu, Cuong Tat Nguyen, Huyen Phuc Do, Carl A. Latkin, Roger C. M. Ho, Cyrus S. H. Ho   +10 more
doaj   +1 more source

Functional disability among the older adult population in Kedah, Malaysia

Clinical Epidemiology and Global Health
Background: Functional disability, defined as acquired difficulty in performing basic daily tasks or more complex tasks needed for independent living.
Ganesh Pandian Balasubramanian, Saraswathi Simansalam, Sireesha Paruchuri, Lydia Lu Qing Yi, Jun Hao Chui   +4 more
doaj   +1 more source

The IMMED Project: Wearable Video Monitoring of People with Age Dementia [PDF]

, 2010
International audienceIn this paper, we describe a new application for multimedia indexing, using a system that monitors the instrumental activities of daily living to assess the cognitive decline caused by dementia.
André-Obrecht, Régine, Benois-Pineau, Jenny, Dartigues, Jean-François, Dovgalecs, Vladislavs, El Khoury, Elie, Gaëstel, Yann, Joly, Philippe, Karaman, Svebor, Mégret, Rémi, Pinquier, Julien, Wannous, Hazem   +10 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Hip fracture. Preliminary results supporting significative correlations between the psychological wellbeing of patients and their relative caregivers [PDF]

, 2016
Background and aim. Hip fracture is one of the major causes of loss of self-sufficiency in older patients. The associated caregiving rehabilitation task often falls to the lot of a member of the patient’s family.
Bellanti, G ., Eleuteri, S., Falaschi, P.   +2 more
core