Results 71 to 80 of about 437,497 (311)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Utilization of Long-Term Care by an Aging Population [PDF]

, 2018
In this brief, authors Reagan Baughman and Jon Hurdelbrink examine the relationship between macroeconomic conditions, as measured by the national unemployment rate, and utilization of long-term care, as measured by respondents’ reports in the Health and ...
Baughma, Reagan, Hurdelbrink, Jon
core   +1 more source

Quality of life, psychological morbidity and family stress in elderly residing in the community [PDF]

, 2015
Este estudo procurou investigar as relações existentes entre morbilidade psicológica, stress familiar e qualidade de vida (QV) da pessoa idosa. A amostra foi constituída por 126 idosos. Os instrumentos utilizados foram: The Lawton Instrumental Activities
Aberg A., Alea N., Alves L., Araújo F., Baldwin R., Baltes M. M., Barrantes-Monge M., Barreto J., Beaumont J. G., Belvis A. G., Benjamin A. E., Bergdahl E., Blazer D. G., Brynes G., Dorantes-Mendoza G., Duarte M. B., Figueiredo D., Folstein M. F., Fonseca A.M., Gott M., Guerreiro M., Harpole L. H., Hayward M. D., Hidalgo R. B., Hudson W. W., Joana Roncon, Jones E. D., Jorm A. F., Kane R. A., Katona C., Keyes C. L., Koster A., Lage I., Lang A. J., Lang A. J., Lawton M. P., Maciel A. C., Maharaj R. G., Maria da Graça Pereira, Menéndez J., Neri A. L., Netuveli G., Ocampo J. M., Ocampo J. M., Pachana N. A., Parker C. J., Ribeiro O., Rodrigues C., Santos F., Sara Lima, Schaie K.W., Schaub R.T., Soneja S., Sousa L., Spar J. E., Stek M. L., Stuck A. E., Tavares D. M., Turagabeci A. R., Vaz Serra A., Yesavage J., Zarit S. H.   +61 more
core   +3 more sources

Pronounced impairment of activities of daily living in posterior cortical atrophy [PDF]

, 2020
Introduction : The impact of several dementia syndromes on activities of daily living (ADLs) has been well documented, but no study has yet investigated functional ability in posterior cortical atrophy (PCA).
Ahmed, Samrah, Blanco-Duque, Cristina, Butler, Christopher, Culley, Siobhan, Hodges, John R., Mioshi, Eneida   +5 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation Between Instrumental Hand Function and Activities of Daily Living in Rheumatoid Arthritis [PDF]

, 2009
Objective: To find the correlation of instrumental handfunction (grip strength, muscle power and range ofmotion) and Activities of Daily Living (ADL) inrheumatoid arthritis patients.Methods: 50 patients of either sex were included in thestudy.
Borah D, Gupta AK, Kumar A, Pandey RM, Singh U, Wadhwa S, Yadav SL   +6 more
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Assessment of functional capacity in patients attending geriatrics outpatient department at Civil Hospital, Ahmedabad

CHRISMED Journal of Health and Research, 2016
Aims: To access the quality of life in terms of functional capacity and to estimate the prevalence of depression among geriatric patients. Settings and Design: A hospital-based study was conducted in Civil Hospital, Ahmedabad between July and September ...
Neeta Mathur
doaj   +1 more source

Publicly funded home care for older people in Ireland: Determinants of utilisation and policy implications [PDF]

, 2012
Background: The majority of older people are independent and self caring. When long-term care is required this is provided across a range of community and residential settings including the older person’s own home.
Foley, MJ, Hickey, M, McClade, C, Molloy, DW, O Caoimh, R, O Regan, N, Timmons, S, Trawley, Steven   +7 more
core   +1 more source