Results 71 to 80 of about 166,808,572 (290)

Growth mixture models for instrumental activities of Daily Living (NEADL) and personal activities of Daily Living (BADL) with corresponding confidence intervals.

, 2023
Growth mixture models for instrumental activities of Daily Living (NEADL) and personal activities of Daily Living (BADL) with corresponding confidence intervals.
Frede Frihagen (4237045), Jorunn L. Helbostad (4910011), Torgeir Bruun Wyller (4237051), Kristin Taraldsen (3442664), Lars Gunnar Johnsen (5937230), Pernille Thingstad (3442658), Shams Dakhil (14856774), Ingvild Saltvedt (3543794), Jūratė Šaltytė Benth (9582242), Leiv Otto Watne (4237057)   +9 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Association of body mass index with disability in activities of daily living in older adults: a systematic review of the literature based on longitudinal data

BMC Public Health
Background The influence of Body Mass Index (BMI) on the functional capacity for daily activities in older adults is a significant concern. Our study is designed to delineate the longitudinal relationship between BMI and the ability of daily living ...
Wang Lingying, Zhu Hong, Chen Hongxiu, Hu Ziyi, Feng Mei, Tang Menglin, Hu Xiuying   +6 more
doaj   +1 more source

Validation of the Everyday Technology Use Questionnaire in a Japanese context

Hong Kong Journal of Occupational Therapy, 2015
Background/Objective: The Everyday Technology Use Questionnaire (ETUQ), which evaluates the perceived relevance of and the perceived ability in everyday technology (ET) use, has demonstrated acceptable psychometric properties in Swedish studies of older ...
Camilla Malinowsky, Anders Kottorp, Rumi Tanemura, Eric Asaba, Toru Nagao, Kazue Noda, Jiro Sagara, Peter Bontje, Lena Rosenberg, Louise Nygård   +9 more
doaj   +1 more source

The efficacy of cognitive interventions on the performance of instrumental activities of daily living in individuals with mild cognitive impairment or mild dementia : protocol for a systematic review and meta-analysis

, 2019
Background: Cognitive changes associated with mild cognitive impairment or mild dementia can lead to difficulties in completing instrumental activities of daily living.
Liu, Karen P.Y. (R17155), Bissett, Michelle, Bye, Rosalind, Tulliani, Nikki (R18504), Tulliani, Nikki, Liu, Karen PY, Fahey, Paul P. (R16945), Bye, Rosalind A. (R7363), Chaudhary, Katrina (R19288), Chaudhary, Katrina, Fahey, Paul   +10 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Effect of Exercise on Physical Function, Daily Living Activities, and Quality of Life in the Frail Older Adults: A Meta-Analysis

, 2017
Chou CH, Hwang CL, Wu YT. Effect of exercise on physical function, daily living activities, and quality of life in the frail older adults: a meta-analysis. Arch Phys Med Rehabil 2012;93:237-44.
吳英黛, Chou, Chih-Hsuan;Hwang, Chueh-Lung;Wu, Ying-Tai   +1 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The bidirectional relationship between activities of daily living and frailty during short-and long-term follow-up period among the middle-aged and older population: findings from the Chinese nationwide cohort study

Frontiers in Public Health
ObjectiveFrailty and activities of daily living (ADL) disability are common conditions among older population. Studies on the bidirectional relationship between frailty and ADL are limited.
Xiaoping Li, Xiaoguang Li, Lu Sun, Liu Yang, Congzhi Wang, Ting Yuan, Yunxiao Lei, Jing Li, Mingming Liu, Dongmei Zhang, Ying Hua, Haiyang Liu, Lin Zhang   +12 more
doaj   +1 more source

Nationwide Study of Basic and Instrumental Activities of Daily Living in Individuals Aged 65+ Living at Home

, 2023
The limitations encountered by aging individuals 65+ in Turkey in their basic and instrumental activities of daily living were examined according to gender and age i.e., specifically for 65-74 and 75+ age groups.
Yildiz, Nadire Gülçin, Aydin, Halide Z., Aydin, Kemal   +2 more
core   +1 more source