Results 91 to 100 of about 437,497 (311)

A Profile of Frail Older Americans and Their Caregivers [PDF]

, 2006
Provides a profile of older Americans and their caregivers, focusing on people age 65 and older who are not in nursing homes, and those with severe disabilities.
Joshua M. Wiener, Richard W. Johnson
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The bidirectional relationship between activities of daily living and frailty during short-and long-term follow-up period among the middle-aged and older population: findings from the Chinese nationwide cohort study

Frontiers in Public Health
ObjectiveFrailty and activities of daily living (ADL) disability are common conditions among older population. Studies on the bidirectional relationship between frailty and ADL are limited.
Xiaoping Li, Xiaoguang Li, Lu Sun, Liu Yang, Congzhi Wang, Ting Yuan, Yunxiao Lei, Jing Li, Mingming Liu, Dongmei Zhang, Ying Hua, Haiyang Liu, Lin Zhang   +12 more
doaj   +1 more source

Role Strains and Mood in Husbands of Women with Fibromyalgia Syndrome: A Test of the Stress Process Model [PDF]

, 2008
Spouses of patients experience role strains as a result of informal caregiving, which has been associated with mood in numerous research studies. However, most research is on female caregivers, and little is known about the experience of male spouses, or
Bigatti, Silvia M., Brothers, Brittany M., Lydon, Jennifer R.   +2 more
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Association between nutrition literacy and physical function limitations among geriatric population in China

BMC Geriatrics
Introduction To assess the relationship between nutrition literacy (NL) and physical function limitations among Chinese older adults. Methods It was a cross-sectional survey carried out in May–July 2023, in Bengbu, China.
Yuhui Sun, Xi Tian, Xiaoting Hu, Huaqing Liu   +3 more
doaj   +1 more source

Performance-based Tools for Assessing Functional Performance in Individuals with Mild Cognitive Impairment

Open Journal of Occupational Therapy, 2015
Background: It is now recognized that individuals with mild cognitive impairment (MCI) face subtle functional declines that can compromise performance in everyday tasks.
Patrícia Belchior, Melanie Holmes, Nathalie Bier, Carolina Bottari, Barbara Mazer, Alexandra Robert, Navaldeep Kaur   +6 more
doaj   +1 more source

Does Working Longer Make People Healthier and Happier? [PDF]

PURPOSE: This study addresses the impact of late-life paid work on physical and psychological well-being. METHODS: Longitudinal data was drawn from the Health and Retirement Survey and the RAND-HRS data base for more than 6,000 individuals aged 59 to 69 ...
Calvo, Esteban
core   +1 more source

A comparison of laboratory, clinical and self-report measures of prospective memory in healthy adults and individuals with brain injury [PDF]

, 2017
Individuals with traumatic brain injury (TBI) have demonstrated deficits in prospective memory (PM) functioning when compared to healthy adults.
Antonia Pereira, Beck A., Beck A. T., David H. K. Shum, Dobbs A. R., Ellis J., Ellis J. A., Ginger Mills, Judi Ellis, Neulinger K., Raskin S., Sarah A. Raskin, Sherer M., Wilson B. A., Woods S. P.   +14 more
core   +3 more sources