Results 81 to 90 of about 18,258 (268)
Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová +10 morewiley +1 more sourceClinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski +12 morewiley +1 more sourceUSP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra +16 morewiley +1 more sourcePETIROC2 based readout electronics optimization for Gamma Cameras and PET detectors [PDF]
, 2017 [EN] Developing front-end electronics to improve charge detection and time resolution in gamma-ray detectors is one of the main tasks to improve performance in new multimodal imaging systems that merge information of Magnetic Resonance Imaging and Gamma ...Monzó Ferrer, José María, Colom Palero, Ricardo José, Lamprou,E., Mázur, Dmytro, González Montoro, Andrea, Hernández Hernández, Liczandro, González Martínez, Antonio Javier, Aguilar -Talens, Albert, Benlloch Baviera, Jose María +8 morecore +1 more sourceMITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson +13 morewiley +1 more sourceOncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan +13 morewiley +1 more sourceOverview of large area triple-GEM detectors for the CMS forward muon upgrade [PDF]
, 2016 We report on the status of the project to install large-area triple-foil gas electron multiplier (GEM) detectors in the end-cap muon system of the Compact Muon Solenoid (CMS) experiment at the LHC operating at the high luminosity planned after the ...Ahmed, W., Cauwenbergh, S, Beni, N., C. Calabria, Sharma, A, Ryu, M S, R. Radogna, Tuuva, T, MUHAMMAD, SALEH, M. Shopova, Iaydjiev, P, Mitselmakher, G, Buontempo, S., M.S. Ryu, Merlin, J A, Stenis, M. Van, Abbaneo, D., P. Aspell, Korytov, A., Yonamine, R, Awan, I., Braibant, S., J. Lee, Yang, Y., Benussi, L, De Oliveira, R, Errico, F, Z. Szillasi, Naimuddin, M, Krutelyov, S, Mal, P. K., W. Ahmed, Zaganidis, N., Ahmad, A, Kim, H., Asawatangtrakuldee, C, Sharma, R, Hoorani, H., Radi, A., F. Guilloux, Dildick, S., R. Venditti, Altieri, P, I. Park, Kamon, T., Abbrescia, M, Barashko, V., Talvitie, J, Majumdar, N, Salva, Sinem, Calabria, C, Majumdar, N., Maggi, M, J.A. Merlin, Zhang, A, J. Bos, Litov, L, Awan, I, Hohlmann, M., A. Colaleo, Dorney, B, Gutierrez, A., Talvitie, J., Rodozov, M., Hoorani, H, Lee, J, Garcia, A. Conde, Marinov, Andrey, Zaganidis, N, Zenoni, F, Vitulo, P, S. Muhammad, D. Abbaneo, Colaleo, A, Nuzzo, S, Dabrowski, M. M., Molnar, J., Volkov, S., Passeggio, G, T. Lenzi, Volkov, S, Hoepfner, Kerstin, Saviano, G, Wang, M., P. Giacomelli, A. Zhang, Jeng, Y G, Szillasi, Z, Yang, U., Mohapatra, A, Hauser, J, Cassese, F., RoyChowdhury, S, P. Vitulo, J. Molnar, M. Wang, A. Cimmino, A. Sharma, Aspell, P, Cassese, F, S. Ferry, S. Mukhopadhyay, Cimmino, Anna, Sultanov, G, Cimmino, A, S. Banerjee, Ban, Y., Muhammad, S, Pant, L.M., Cauwenbergh, S., S. Choi, Piccolo, D, Fenyvesi, A, T. Tuuva, Van Stenis, M, Ferry, S., Braghieri, A, Mal, P K, Choi, S., U. Yang, Dabrowski, M.M., A. Celik, M. Rodozov, Rodozov, M, Passeggio, G., H. Kim, Czellar, S, Bouhali, O, E. Oliveri, Marchioro, A, M. Naimuddin, Oliveri, E, Abbas, M., Rodrigues, A., P. Karchin, D. Piccolo, Dildick, S, S. Dildick, Guilloux, F, Sharma, A., Magnani, A, Mandal, K, Riccardi, C, G. de Robertis, P. Iaydjiev, Yang, Y, Barashko, V, A. Fenyvesi, Yang, U, G. Rashevski, Aboamer, O., Jeng, Y. G., de Robertis, G., F. Cassese, Buontempo, S, Barria, P, Ban, Y, Ranieri, A., L. Ropelewski, Abbaneo, D, Barria, P., Celik, A., Mal, P.K., V. Bhopatkar, Kamon, T, Ferry, S, Radi, A, Abbas, M, M. Caponero, L. Litov, Czellar, S., Aspell, P., N. Beni, Y. Yang, Bally, S, Shopova, M, Gilmore, J., Hauser, J., A. Madorsky, Loddo, F, Merlin, J. A., Radogna, R, Ryu, G, T. Maerschalk, Hadjiiska, R. M., Assran, Y, Braibant, S, Pavlov, B., Conde Garcia, A, D. Wang, Bianco, S., Guiducci, L., J. Hauser, Golovtsov, V, Lenzi, T., Vitulo, P., Tytgat, M., A. Radi, Iaydjiev, P., R. Yonamine, I. Furic, P. Altieri, Abbas, Mahmoud, Karchin, P, Radogna, R., Giacomelli, P, Marchioro, A., K. Mandal, L. Guiducci, Kim, H, M. Hohlmann, Raffone, G, Bencze, G., C. Asawatangtrakuldee, S.K. Swain, A. Rodrigues, Pant, L. M., A. Kumar, S. Nuzzo, Guilloux, F., Mohanty, A. K., Piccolo, D., Acosta, D, Bally, S., S. Cauwenbergh, M.M. Dabrowski, Kumar, A., Vai, I., Verwilligen, P, B. Pavlov, Endroczi, G., Paolucci, P., Y. Assran, Rashevski, G, Magnani, A., J. Gilmore, Hoepfner, K., S. Bally, Vai, I, Ryu, M. S., Salva, S, G. Saviano, Akl, M. Abi, Gutierrez, A, G. Passeggio, Tatarinov, A, N. Majumdar, S. Colafranceschi, Cavallo, F. R., Naimuddin, M., Roychowdhury, S., Colaleo, A., Y.G. Jeng, S. Volkov, M. Choi, Venditti, R, Muhammad, S., Celik, A, S. Czellar, A. Tatarinov, Korytov, A, Rashevski, G., F. Loddo, Mukhopadhyay, S, Dabrowski, M M, Y. Ban, F. Zenoni, G. Endroczi, V. Golovtsov, Paolucci, P, A. Ahmad, Verhagen, E, P. Paolucci, Philipps, B., Dildick, Sven, Philipps, B, De Lentdecker, G., de Robertis, G, Ropelewski, L., Guiducci, L, I. Vai, Wang, D, Nuzzo, S., Ranieri, A, Cimmino, A., Zenoni, F., Errico, F., Wang, M, Ahmad, A., Swain, S K, K. Hoepfner, Castaneda, A, Vitulo, R., Ropelewski, L, Mitselmakher, G., Caponero, M., P.K. Mal, Ahmed, W, G. Mitselmakher, Benussi, L., Abi Akl, M, P. Barria, Zhang, A., S. Salva, Shah, A H, Bhopatkar, V, Postema, H., Kumar, A, Mohanty, A K, Bianco, S, Litov, L., Christiansen, J., H. Hoorani, Szillasi, Z., Park, I., Verwilligen, Piet, C. Riccardi, A. Marchioro, Venditti, R., A. Aleksandrov, A. Mohapatra, Braghieri, A., M. Abbas, A. Marinov, A. Braghieri, Endroczi, G, A. Conde Garcia, A.H. Shah, Aboamer, O, Sturdy, J., B. Dorney, Tuuva, T., De Oliveira, R., Lenzi, T, Krutelyov, S., T. Kamon, Shopova, M., Riccardi, C., Verhagen, E., Furic, L., Beni, N, Hadjiiska, R M, Ryu, M.S., O. Aboamer, Madorsky, A., Marinov, A., S. Braibant, Molnar, J, J. Christiansen, Cavallo, F.R., Caputo, C, Mukhopadhyay, S., M. Maggi, Tytgat, M, Sharma, R., A. Gutierrez, A.K. Mohanty, Aleksandrov, A, A. Magnani, D. Acosta, Asawatangtrakuldee, C., Colafranceschi, S, Park, I, O. Bouhali, Bos, J, Aleksandrov, Alexander, Christiansen, J, Hadjiiska, R.M., M. Abbrescia, Abi Akl, M., Caponero, M, Altieri, P., Mohapatra, A., Mandal, K., Bos, J., M. Van Stenis, Vai, I. (ORCID:0000-0003-0037-5032), Giacomelli, P., Postema, H, A. Ranieri, Choi, M., J. Sturdy, Furic, I, Sturdy, J, Shah, A. H., C. Caputo, I. Awan, Puig Baranac, A., Maerschalk, T, V. Barashko, Assran, Y., Bhopatkar, V., Loddo, F., Dorney, B., Vorobyev, A, Banerjee, S., Conde Garcia, A., R. Sharma, Raffone, G., van Stenis, M., Golovtsov, V., L.M. Pant, F.R. Cavallo, Pant, L M, Fenyvesi, A., Saviano, G., Banerjee, S, Karchin, P., G. De Lentdecker, Colafranceschi, S., G. Bencze, Furic, I., SAVIANO, Giovanna, Rodrigues, A, Salva, S., B. Philipps, Acosta, D., De Lentdecker, G, Caputo, C., Hohlmann, M, R.M. Hadjiiska, Merlin, J.A., M. Tytgat, P. Verwilligen, Madorsky, A, A. Puig Baranac, E. Verhagen, A. Castaneda, F. Errico, Oliveri, E., Swain, S.K., Pavlov, B, Hoepfner, K, Ryu, G., L. Benussi, N. Zaganidis, Puig Baranac, A, Safonov, A, Gilmore, J, S. Buontempo, Philipps, Barthel, Verwilligen, P., Aleksandrov, A., J. Talvitie, Swain, S. K., Vorobyev, A., Wang, D., Mohanty, A.K., G. Raffone, H. Postema, A. Safonov, Sultanov, G., Marinov, A, Yonamine, R., Tatarinov, A., S. Bianco, A. Vorobyev, Bencze, G, Maerschalk, T., Zaganidis, Nikolaos, S. Krutelyov, Lee, J., R. De Oliveira, G. Sultanov, G. Ryu, Jeng, Y.G., Choi, M, Abbrescia, M., Bouhali, O., Maggi, M., M. Abi Akl, Castaneda, A., Choi, S, S. RoyChowdhury, Cavallo, F R, Shah, A.H., A. Korytov, Safonov, A., Calabria, C., Tytgat, Michael +479 morecore +1 more sourceSystematic Study of a SiPMT array readout for fast time-of-flight detectors [PDF]
, 2014 Time-of-flight detectors, based on scintillation counters, may use conventional photomultipliers
for the readout. Problems arise in presence of external magnetic fields.M. Bonesini, NARDO', ROBERTO, M. Rossella, R. Bertoni, BARNABA', ORLANDO, M. C. Prata, DE BARI, ANTONIO +6 morecore
