Results 41 to 50 of about 103,546 (243)
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Adding traceability to an educational IDE : a thesis presented in partial fulfilment of the requirements for the Master degree in Computer Science at Massey University, Manawatu, New Zealand [PDF]
, 2016 High dropout and failure rate in introductory programming courses indicate the need to improve programming comprehension of novice learners. Some of educational tools have successfully used game environments to motivate students. Our approach is based
Sui, Li
core
EffectiveSan: Type and Memory Error Detection using Dynamically Typed C/C++
, 2018 Low-level programming languages with weak/static type systems, such as C and C++, are vulnerable to errors relating to the misuse of memory at runtime, such as (sub-)object bounds overflows, (re)use-after-free, and type confusion. Such errors account for
Akritidis P. +10 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
CONFLLVM: A Compiler for Enforcing Data Confidentiality in Low-Level Code
, 2019 We present an instrumenting compiler for enforcing data confidentiality in low-level applications (e.g. those written in C) in the presence of an active adversary.
Bhatu, P. +8 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Monitoring-Oriented Programming: A Tool-Supported Methodology for Higher Quality Object-Oriented Software [PDF]
, 2004 This paper presents a tool-supported methodological paradigm for object-oriented software development, called monitoring-oriented programming and abbreviated MOP, in which runtime monitoring is a basic software design principle.
Chen, Feng +2 more
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Computer signal processing for ultrasonic attenuation and velocity measurements for material property characterizations [PDF]
Instrumentation and computer programming concepts that were developed for ultrasonic materials characterization are described. Methods that facilitate velocity and attenuation measurements are outlined.
Vary, A.
core +1 more source