Results 91 to 100 of about 411,109 (307)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules

International Journal of Endocrinology, 2017
Aim. Insulin-like growth factor-1 (IGF-1) is a potent mitogen for many cells. IGF-1 plays a role in the pathogenesis of various tumors with its mutagenic and antiapoptotic properties. The aim of this study was to determine both the serum and intranodular
Ayfer Altas, Fatih Kuzu, Dilek Arpaci, Mustafa Unal, Murat Can, Figen Barut, Furuzan Kokturk, Sevil Uygun Ilikhan, Taner Bayraktaroglu   +8 more
doaj   +1 more source

Comprehensive profiling of zebrafish hepatic proximal promoter CpG island methylation and its modification during chemical carcinogenesis [PDF]

, 2011
Background\ud DNA methylation is an epigenetic mechanism associated with regulation of gene expression and it is modulated during chemical carcinogenesis.
Chipman, J Kevin, Gong, Zhiyuan, Mirbahai, Leda, Williams, Timothy D, Zhan, Huiqing   +4 more
core   +4 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

QUASI-EXPERIMENTAL EVALUATION OF ZINC SUPPLEMENTATION ON MEAN SERUM INSULIN LIKE GROWTH FACTOR-1 (IGF-1) AND INSULIN LIKE GROWTH FACTOR BINDING PROTEIN-3 (IGFBP-3) LEVELS IN PAKISTANI SHORT STATURED CHILDREN

Pakistan Armed Forces Medical Journal, 2020
Objective: To investigate the influence of supplemental zinc on the levels of insulin like growth factor-1 (IGF-1) and insulin like growth factor binding protein-3 (IGFBP-3) in short statured Pakistani children of 3-6 years of age. Study Design: Quasi-
Sadia Kirn, Amir Ijaz, Safia Fatima, Dilshad Ahmed Khan, Sarmad Nasir   +4 more
doaj  

Estimation of insulin-like growth factor binding protein -1 in premature heart contraction patients [PDF]

Journal of Bioscience and Applied Research
This study was conducted to provide an approach for the diagnosis and prognosis of atrial and ventricular presystole, with a particular focus on insulin-like growth factor-binding protein (IGF-1).
NOOR Haider, Arshad AL-DUJAILI
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

The relationship between the insulin-like growth factor-1 axis, weight loss, an inflammation-based score and survival in patients with inoperable non-small cell lung cancer [PDF]

, 2010
<b>Background & aims:</b> The involvement of a systemic inflammatory response, as evidenced by the Glasgow Prognostic Score (GPS), is associated with weight loss and poor outcome in patients with non-small cell lung cancer.
Forrest, L.M., McMillan, D.C., Meek, C.L., Wallace, A.M.   +3 more
core   +1 more source

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin. [PDF]

, 2014
A long-standing issue in the field of signal transduction is to understand the cross-talk between receptor tyrosine kinases (RTKs) and heterotrimeric G proteins, two major and distinct signaling hubs that control eukaryotic cell behavior.
Abagyan, Ruben, Aznar, Nicolas, Ear, Jason, Garcia-Marcos, Mikel, Ghosh, Pradipta, Kufareva, Irina, Lin, Changsheng, Lopez-Sanchez, Inmaculada, Midde, Krishna   +8 more
core   +1 more source