Biomarkers of systemic inflammation and growth in early infancy are associated with stunting in young Tanzanian children [PDF]
, 2018 Stunting can afflict up to one-third of children in resource-constrained countries. We hypothesized that low-grade systemic inflammation (defined as elevations in serum C-reactive protein or alpha-1-acid glycoprotein) in infancy suppresses the growth ...
Aboud, Said +9 more
core +1 more source
Late Effects of Disturbed IGF Signaling in Congenital Diseases. [PDF]
, 2007 The biologic effects of insulin-like growth factor-1 (IGF-1) are mediated by specific cell surface receptors. IGF-1 binding to the extracellular -subunits activates the tyrosine kinase intrinsic to the cytoplasmic portion of the IGF-1 receptor ...
Cianfarani S +4 more
core +1 more source
Regulation of human villous trophoblast by insulin-like growth factors and insulin-like growth factor-binding protein-1 [PDF]
Journal of Endocrinology, 2004 Many studies have implicated the insulin-like growth factors (IGFs) and insulin-like growth factor-binding protein-1 (IGFBP-1) in the control of the feto–maternal interface of human pregnancy, but many of the data are from cell lines derived from primary trophoblast or from extravillous trophoblast.
F A, Hills +3 more
openaire +2 more sources
IGF-Binding Proteins: Why Do They Exist and Why Are There So Many?
Frontiers in Endocrinology, 2018 Insulin-like growth factors (IGFs) are key growth-promoting peptides that act as both endocrine hormones and autocrine/paracrine growth factors. In the bloodstream and in local tissues, most IGF molecules are bound by one of the members of the IGF ...
John B. Allard, Cunming Duan
doaj +1 more source
Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells [PDF]
, 2007 The insulin receptor substrate-1 (IRS-1), a docking protein for both the type 1 insulin-like growth factor receptor (IGF-IR) and the insulin receptor, is known to send a mitogenic, anti-apoptotic, and anti-differentiation signal. Several micro RNAs (miRs)
Baserga, Renato +5 more
core +2 more sources
Tumor Biology, 2017 Insulin-like growth factor-binding protein-3 acts as a tumor suppressor that inhibits the PI3K/AKT signaling pathway due to blocking insulin growth factor-1 binding to its receptor.
Hsiu-Hua Wang +5 more
doaj +1 more source
Insulin-like growth factor binding protein 1 DNA methylation in type 2 diabetes
Egyptian Journal of Medical Human Genetics, 2021 Background Type 2 diabetes (T2D) is a complex trait in humans. Several environmental and hereditary factors contribute to the overall pathogenesis of this disease.
Sally M. Hafez +7 more
doaj +1 more source
Accuracy of Phosphorylated Insulin-Like Growth Factor Binding Protein-1 in Predicting Preterm Labour [PDF]
Journal of Biomedical & Clinical Research, 2020 Preterm birth is the most common cause of perinatal morbidity and mortality worldwide. The routine method for predicting premature birth is the measurement of the cervical length.
Elitsa Gyokova +4 more
doaj +3 more sources
Identification and characterization of insulin-like growth factor receptors on adult rat cardiac myocytes: linkage to inositol 1,4,5-trisphosphate formation. [PDF]
, 1992 Cultured cardiac myocytes from adult Sprague-Dawley rats express both insulin-like growth factor-I (IGF-I) receptors and insulin-like growth factor-II/mannose 6-phosphate (IGF-II/Man6P) receptors and respond to IGF-I with a dose-dependent accumulation of
Berg, Ingeborg +5 more
core +1 more source
Insulin-like growth factor-I and its binding proteins in healthy mothers and their newborns [PDF]
Einstein (São Paulo), 2004 Objective: To determine serum levels of insulin-like growth factor-I, free insulin-like growth factor-I and its binding proteins in maternalserum and in cord blood of two groups of newborns with differentbirth weights.
Rosanna Velleca Lima +3 more
doaj