Results 51 to 60 of about 241,190 (311)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Growth Hormone Receptor Gene Expression Increase Reflects Nutritional Status Improvement in Patients Affected by Crohn's Disease

Frontiers in Pediatrics, 2018
Background: We proposed to verify the role of growth hormone receptor gene expression in growth failure of children with Crohn's disease (CD).Methods: We measured serum levels of growth hormone binding protein (GHBP) and insulin-like growth factor-I (IGF-
Sara Pagani, Elena Bozzola, Caterina Strisciuglio, Cristina Meazza, Erasmo Miele, M. Malamisura, Paola De Angelis, Mauro Bozzola   +7 more
doaj   +1 more source

Glucokinase links Kruppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease [PDF]

, 2011
The polymorphism, KLF6-IVS1-27A, in the Krüppel-like factor 6 (KLF6) transcription factor gene enhances its splicing into antagonistic isoforms and is associated with delayed histological progression of nonalcoholic fatty liver disease (NAFLD).
Gastaldelli, Amalia, Lee, Y., Isabel Fiel, Elisabetta Bugianesi, Miele, L., Lee, U., Bugianesi, E., Emma Buzzigoli, Andrea Mari, Pascoe, L., Mark Walker, Christopher P. Day, Burt, Alastair D., Walker, M., Bechmann, L., Hui, Kei Y, Fiel, I., Buzzigoli, E., Bechmann, Lars P., Miele, Luca, Fiel, Isabel., Luca Miele, Mari, Andrea, Patman, G., Ursula Muñoz, Day, Christopher P., Vetter, Diana., Burt, A., Lee, Young-Min., Munoz, Ursula., Hannivoort, Rebekka A., Alastair D. Burt, Amalia Gastaldelli, Walker, Mark., Agius, Loranne, Mari, A., Agius, Loranne., et al., Buzzigoli, Emma, Walker, Mark, Loranne Agius, Scott L. Friedman, Lee, Young-Min, Pascoe, Laura., Miele, Luca., Munoz, Ursula, Hui, K., Day, C., Laura Pascoe, Pascoe, Laura, Gastaldelli, Amalia., Fiel, Isabel, Ursula E. Lee, Gillian L. Patman, Munoz, U., Kei Y. Hui, Agius, L., Mari, Andrea., Vetter, D., Demetrio Ciociaro, Ciociaro, D., Buzzigoli, Emma., Lars P. Bechmann, Helen L. Reeves, Patman, Gillian L., Hannivoort, Rebekka A ., Ciociaro, Demetrio, Ciociaro, Demetrio., Mu?oz, Ursula, Bugianesi, Elisabetta, Diana Vetter, Reeves, Helen L., Hannivoort, R., Lee, Ursula E., Rebekka A. Hannivoort, Bugianesi, Elisabetta., Young-Min Lee, Vetter, Diana, Hui, Kei Y., Friedman, Scott L., Gastaldelli, A.   +80 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Insulin-like growth factor 1 and insulin-like growth factor binding protein-3 as predictive biomarkers of depression and migraine in obese women

The Egyptian Journal of Internal Medicine, 2019
Introduction Obesity and its comorbidity, depression and migraine, are highly prevalent conditions and public health problems of enormous scope that are responsible for the significant quality of life impairment and financial cost.
Nearmeen M Rashad, Ahmed F Gomaa, Hanan M Sabry, Amira A Fouad, Shereen M El Shabrawy   +4 more
doaj   +1 more source

IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells [PDF]

, 2012
The cysteine-type peptidase cathepsin X is highly upregulated in several cancers and presumably promotes tumor invasion through bypassing cellular senescence. Here, we present first evidence that the underlying mechanism may involve the regulation of the
Kraus, Steffen, Bunsen, Thea, Fruth, Maximilian, Nägler, Dorit K.   +3 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Cumulative mutagenesis of the basic residues in the 201-218 region of insulin-like growth factor (IGF)-binding protein-5 results in progressive loss of both IGF-I binding and inhibition of IGF-I biological action

, 2005
We have reported previously that mutation of two conserved nonbasic amino acids (G203 and Q209) within the highly basic 201–218 region in the C-terminal domain of IGF-binding protein-5 (IGFBP-5) decreases binding to IGFs.
Kelly, S.M., Tonner, Elizabeth, Gow, I.F., Gow, Iain F, Clegg, Roger A, Allan, Gordon J., Clegg, Roger A., Beattie, J., Beattie, James, Flint, David J., Allan, G.J., Flint, D.J., Gow, Iain F., Shand, J., Tonner, E., Szymanowska, M., Phillips, K., Shand, John H, Allan, Gordon J, Phillips, Kirsten, Kelly, Sharon M, Clegg, R.A., Shand, John H., Flint, David J, Szymanowska, Malgorzata, Kelly, Sharon M.   +25 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Estudio inmunocitoquímico y molecular de cultivo primario de tejido molar

Biomédica: revista del Instituto Nacional de Salud, 2006
Introducción. La enfermedad trofoblástica gestacional comprende un conjunto de patologías caracterizadas por crecimiento e invasión anómalos del trofoblasto.
Yinth Andrea Bernal, Luis Eduardo Díaz, Jinneth Acosta, Cecilia Crane, Stella Carrasco-Rodríguez, Antonio José Bermúdez, Myriam Sánchez-Gómez   +6 more
doaj   +1 more source