Results 31 to 40 of about 414,372 (151)

Hybrid closed-loop glucose control with faster insulin aspart compared with standard insulin aspart in adults with type 1 diabetes: A double-blind, multicentre, multinational, randomized, crossover study. [PDF]

, 2021
AIM: To evaluate the use of hybrid closed-loop glucose control with faster-acting insulin aspart (Fiasp) in adults with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: In a double-blind, multinational, randomized, crossover study, 25 adults with T1D ...
Evans, Mark, Hovorka, Roman, Nathan Cohen, Judy Sibayan, Calhoun, Peter, Bally, Lia, Sara Hartnell, Mader, Julia, Sibayan, Judy, Malgorzata E. Wilinska, Cohen, Nathan, Hartnell, Sara, Hood Thabit, Mader, Julia K, Ashcroft, Nicole L, Lalantha Leelarathna, Boughton, Charlotte K, Mark Evans, David Herzig, Lia Bally, Tina Poettler, Thabit, Hood; id_orcid, Thabit, Hood, Poettler, Tina, Herzig, David, Nicole L. Ashcroft, Peter Calhoun, Roman Hovorka, Ashcroft, Nicole, Wilinska, Malgorzata E, Wilinska, Malgorzata, Julia K. Mader, Boughton, Charlotte, Charlotte K. Boughton, Leelarathna, Lalantha   +34 more
core   +5 more sources

Pre-meal insulin aspart compared with pre-meal soluble human insulin in type 1 diabetes

, 2006
Insulin aspart has been shown, in medium-term studies, to achieve reductions in HbA1c without increasing the risk of major hypoglycaemia compared with pre-meal human insulin.
Faber J, Friberg HH, Hallgren P, Usadel KH, Sane T, Grill V, Home PD   +6 more
core   +5 more sources

Adding pioglitazone to insulin containing regimens in type 2 diabetes : systematic review and meta-analysis [PDF]

, 2009
Background Type 2 diabetes is treated in a stepwise manner, progressing from diet and physical activity to oral antidiabetic agents and insulin. The oral agent pioglitazone is licensed for use with insulin when metformin is contraindicated or not ...
Waugh Norman, Christine Clar, Clar Christine, Waugh, Norman, Norman Waugh, Royle Pamela, Clar, C., Royle, Pamela, Pamela Royle   +8 more
core   +1 more source

Projected long-term outcomes in patients with type 1 diabetes treated with fast-acting insulin aspart versus conventional insulin aspart in the UK setting [PDF]

, 2017
Aims: Many patients with type 1 diabetes mellitus (T1DM) fail to achieve optimal glycemic control and mealtime insulins that more closely match physiological insulin secretion can help improve treatment.
Heller, S., Buchs, S., Simon R. Heller, Barnaby Hunt, Valentine, W.J., Sandberg, A., Sarah Buchs, Hunt, B., William J. Valentine, Russell-Jones, D., Anna Sandberg, David Russell‐Jones   +11 more
core   +1 more source

Clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the West Bengal cohort of the A 1 chieve study

Indian Journal of Endocrinology and Metabolism, 2013
Background: The A 1 chieve, a multicentric (28 countries), 24-week, non-interventional study evaluated the safety and effectiveness of insulin detemir, biphasic insulin aspart and insulin aspart in people with T2DM (n = 66,726) in routine clinical care ...
Satinath Mukhopadhyay, Nilanjan Sengupta, Sujoy Ghosh   +2 more
doaj   +1 more source

Clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the Northern Tunisia cohort of the A 1 chieve study

Indian Journal of Endocrinology and Metabolism, 2013
Background: The A 1 chieve, a multicentric (28 countries), 24-week, non-interventional study evaluated the safety and effectiveness of insulin detemir, biphasic insulin aspart and insulin aspart in people with T2DM (n = 66,726) in routine clinical care ...
Samira Blouza, Henda Jamoussi
doaj   +1 more source

Hypoglycemia in Type 2 Diabetes Patients Substituted with Insulin Degludec Aspart from Premixed Insulin Therapy: a Quasi Experimental Study

Pakistan Armed Forces Medical Journal
Objective: To determine whether Insulin Degludec Aspart is associated with a reduced risk of hypoglycemia as compared to premixed Insulin aspart therapy in type-2 diabetes mellitus patients. Study Design: Quasi-experimental study Place and Duration
Komal Mumtaz Malik, Sadia Zafar, Shabana Ali, Mudassir Noor, Noaman Ishaq   +4 more
doaj   +1 more source

Fast-acting insulin aspart versus insulin aspart in the setting of insulin degludec-treated type 1 diabetes: Efficacy and safety from a randomized double-blind trial [PDF]

, 2018
Aim: To evaluate the efficacy and safety of mealtime or post-meal fast-acting insulin aspart (faster aspart) vs mealtime insulin aspart (IAsp), both in combination with insulin degludec, in participants with type 1 diabetes (T1D).
Liang, B., Buse, J.B., Buchholtz, K., John B. Buse, Ludger Rose, Mosenzon, O., Carlson, A.L., Anders L. Carlson, Horio, H., Kristine Buchholtz, Komatsu, M., Rose, L., Takashi Kadowaki, Hiroshi Horio, Bo Liang, Mitsuhisa Komatsu, Ofri Mosenzon, Kadowaki, T.   +17 more
core   +1 more source

Clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the Punjab cohort of the A 1 chieve study

Indian Journal of Endocrinology and Metabolism, 2013
Background: The A 1 chieve, a multicentric (28 countries), 24-week, non-interventional study evaluated the safety and effectiveness of insulin detemir, biphasic insulin aspart and insulin aspart in people with T2DM (n = 66,726) in routine clinical care ...
Parminder Singh, K P Singh, Gagan Priya, Rohit Kapoor   +3 more
doaj   +1 more source

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, EarlyView.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source