Emerging Insulin Analogues: A Glimpse into How Insulin Analogues May Look in the near Future [PDF]
PharmaceuticsThe use of insulin as a treatment for diabetes mellitus has been marred by several challenges. These setbacks incurred in an attempt to better manage diabetes, together with past innovative strategies, have encouraged science and the clinical community ...
Ntethelelo Sibiya +4 more
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Minimizing Mitogenic Potency of Insulin Analogues Through Modification of a Disulfide Bond [PDF]
Frontiers in Endocrinology, 2022 The mechanisms by which insulin activates the insulin receptor to promote metabolic processes and cellular growth are still not clear. Significant advances have been gained from recent structural studies in understanding how insulin binds to its receptor.
Shee Chee Ong +7 more
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The Current Situation Regarding Long-Acting Insulin Analogues Including Biosimilars Among African, Asian, European, and South American Countries; Findings and Implications for the Future [PDF]
Frontiers in Public Health, 2021 Background: Diabetes mellitus rates continue to rise, which coupled with increasing costs of associated complications has appreciably increased global expenditure in recent years. The risk of complications are enhanced by poor glycaemic control including
Brian Godman +88 more
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Hypoglycemia frequency and treatment satisfaction in patients receiving insulin analogues for treatment of type 1 diabetes mellitus [PDF]
Archives of Endocrinology and Metabolism, 2021 Objective: The aim of this study was to evaluate the frequency of hypoglycemia and the treatment satisfaction in patients with type 1 diabetes (T1D) using insulin analogues. Subjects and methods: This observational retrospective study included 516 adult
Gabriela Berlanda +8 more
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Regular human insulins versus rapid-acting insulin analogues in children and adolescents with type 1 diabetes: a systematic review with meta-analysis and trial sequential analysis [PDF]
BMJ OpenObjectives To assess the beneficial and harmful effects of regular human insulins versus rapid-acting insulin analogues in children and adolescents with type 1 diabetes.Design Systematic review of randomised clinical trials with meta-analysis and trial ...
Sophie Juul +2 more
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Regular human insulins versus rapid-acting insulin analogues in children and adolescents with type 1 diabetes: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis [PDF]
Systematic ReviewsBackground Type 1 diabetes is a serious, chronic disorder with an increasing incidence among children and adolescents. Glycemic control in individuals with type 1 diabetes is better managed through a basal-bolus regimen with either regular human or rapid-
Johanne Juul Petersen +6 more
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Identification of Host Insulin Binding Sites on Schistosoma japonicum Insulin Receptors. [PDF]
PLoS ONE, 2016 Schistosoma japonicum insulin receptors (SjIRs) have been identified as encouraging vaccine candidates. Interrupting or blocking the binding between host insulin and the schistosome insulin receptors (IRs) may result in reduced glucose uptake leading to ...
Rachel J Stephenson +5 more
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Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analogues. [PDF]
PLoS ONE, 2012 BACKGROUND: Insulin analogues comprising acidic amino acid substitutions at position B10 have previously been shown to display increased mitogenic potencies compared to human insulin and the underlying molecular mechanisms have been subject to much ...
Tine Glendorf +7 more
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Engineering of insulin receptor isoform-selective insulin analogues. [PDF]
PLoS ONE, 2011 BACKGROUND: The insulin receptor (IR) exists in two isoforms, A and B, and the isoform expression pattern is tissue-specific. The C-terminus of the insulin B chain is important for receptor binding and has been shown to contact the IR just adjacent to ...
Tine Glendorf +5 more
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Lower rate of cardiovascular complications in patients on bolus insulin analogues: a retrospective population-based cohort study. [PDF]
PLoS ONE, 2013 BackgroundFew studies are available evaluating the impact of rapid-acting insulin analogues on long-term diabetes outcomes. Our aim was to compare the use of rapid-acting insulin analogues versus human regular insulin in relation to the occurrence of ...
Simona Cammarota +14 more
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