Results 11 to 20 of about 28,682 (212)

Effect of insulin analogues on insulin/IGF1 hybrid receptors: increased activation by glargine but not by its metabolites M1 and M2. [PDF]

PLoS ONE, 2012
BACKGROUND: In diabetic patients, the pharmacokinetics of injected human insulin does not permit optimal control of glycemia. Fast and slow acting insulin analogues have been developed, but they may have adverse properties, such as increased mitogenic or
Cécile Pierre-Eugene, Patrick Pagesy, Tuyet Thu Nguyen, Marion Neuillé, Georg Tschank, Norbert Tennagels, Cornelia Hampe, Tarik Issad   +7 more
doaj   +1 more source

Modern basal insulins: an ongoing story or the start of a new era?

Сахарный диабет, 2015
Basal insulin represents an essential tool in the treatment of both type 1 and type 2 diabetes mellitus. The development of insulin analogues has improved the possibilities of diabetes treatment.
Ivan Ivanovich Dedov
doaj   +1 more source

Elements of metabolic control in children with type 1 diabetes before and after introduction to insulin analogues [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2011
Introduction. Diabetes mellitus type 1 (T1DM) in children is characterized by unstable course. A significant number of studies shows that introduction to insulin analogues treatment aims towards better control of the disease. Objective. The assessment
Baloš Ljiljana, Sajić Silvija, Zdravković Vera   +2 more
doaj   +1 more source

Basal Insulin Analogues

Endocrinology Research and Practice, 2022
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Olcay Gedik
doaj   +2 more sources

Insulin analogues versus human insulin in type 1 diabetes: direct and indirect meta-analyses of efficacy and safety

Brazilian Journal of Pharmaceutical Sciences, 2013
All patients with Diabetes Mellitus (DM) receive insulin therapy. In this study, we evaluated the efficacy, safety and tolerability of human insulin and insulin analogues.
Andréia Cristina Conegero Sanches, Cassyano Januário Correr, Rafael Venson, Patrícia Rodrigues Gonçalves, Mariana Martins Garcia, Mário Sérgio Piantavini, Roberto Pontarolo   +6 more
doaj   +1 more source

Insulin analogues and cancer: a note of caution

Frontiers in Endocrinology, 2014
In view of the lifelong exposure and large patient populations involved, insulin analogues with an increased mitogenic effect in comparison to human insulin may potentially constitute a major health problem, since these analogues may possibly induce the ...
Joseph A.M.J.L. eJanssen, Aimee J. Varewijck   +1 more
doaj   +1 more source

Effects of metformin on body weight in patients with type 2 diabetes mellitus,receiving insulin analogue treatment

Сахарный диабет, 2013
Aims. To study the dynamics of body weight, waist circumference, blood lipid and insulin demand in patients with type 2 diabetes mellitus (T2DM) during first year of combined treatment with metformin and insulin analogues, compared with insulin analogue
Tatiana Ivanovna Romantsova, T Sh Dzhavakhishvili, O V Roik   +2 more
doaj   +1 more source

Differences in bioactivity between human insulin and insulin analogues approved for therapeutic use- compilation of reports from the past 20 years

Diabetology & Metabolic Syndrome, 2011
In order to provide comprehensive information on the differences in bioactivity between human insulin and insulin analogues, published in vitro comparisons of human insulin and the rapid acting analogues insulin lispro (Humalog®), insulin aspart ...
Werner Haim, Chantelau Ernst A
doaj   +1 more source

Glycaemic control and prevalence of hypoglycaemic events in children and adolescents with type 1 diabetes mellitus treated with insulin analogues [PDF]

Vojnosanitetski Pregled, 2014
Background/Aim. An ideal insulin regimen for children and adolescents with type 1 diabetes mellitus (T1DM) should be physiological, flexibile and predictable, protecting against hypoglycaemia.
Plavšić Ljiljana, Mitrović Katarina, Todorović Slađana, Vuković Rade, Milenković Tatjana, Zdravković Dragan   +5 more
doaj   +1 more source

Maternal and neonatal outcomes with the use of long acting, compared to intermediate acting basal insulin (NPH) for managing diabetes during pregnancy: a systematic review and meta-analysis

Diabetology & Metabolic Syndrome, 2022
Background To assess the impact of long-acting insulin analogues, compared to intermediate acting neutral protamine Hagedron (NPH), on maternal, perinatal and neonatal outcomes.
Jijiao Wang, Xiaochen Ji, Ting Liu, Nan Zhao   +3 more
doaj   +1 more source