Results 21 to 30 of about 28,682 (212)

Insulin Analogues (Insulin Detemir and Insulin Aspart) Versus Traditional Human Insulins (NPH Insulin Regular Human Insulin) in Basal Bolus Therapy for Patients with Type-I Diabetes Mellitus

Pakistan Armed Forces Medical Journal
Objective: To compare the effect of Insulin analogues (Insulin Detemir and Insulin Aspart) versus Traditional Human Insulins (NPH Insulin Regular Human Insulin) in basal bolus therapy for patients with Type-I Diabetes Mellitus.
Muhammad Hamza Zaheer, Muhammad Adnan Manzar, Bilal Ahmed, Roshaan Tahir, Muhammad Hamza Qureshi, Shawnze Akhtar   +5 more
doaj   +1 more source

Individualisation of basal insulin therapy of type 2 diabetes: evidence from large randomized controlled trials

Сахарный диабет, 2023
Initiation of insulin therapy with basal insulin analogues has become the standard of care for type 2 diabetes mellitus (T2DM). Timely administration of insulin allows not only to slow down the progression of type 2 diabetes, but also to reduce the ...
S. V. Nedogoda, I. N. Barykina, A. S. Salasyuk, V. O. Lutova, E. A. Popova   +4 more
doaj   +1 more source

Computational study of the activity, dynamics, energetics and conformations of insulin analogues using molecular dynamics simulations: Application to hyperinsulinemia and the critical residue B26

Biochemistry and Biophysics Reports, 2017
Due to the increasing prevalence of diabetes, finding therapeutic analogues for insulin has become an urgent issue. While many experimental studies have been performed towards this end, they have limited scope to examine all aspects of the effect of a ...
Anastasios Papaioannou, Serdar Kuyucak, Zdenka Kuncic   +2 more
doaj   +1 more source

Modern approach to the evaluation of the pharmacokinetics and pharmacodynamics of biosimilar recombinant human insulin and insulin analogues in I phase clinical study

Сахарный диабет, 2016
The quality, pharmacokinetic and pharmacodynamic profiles, safety and immunogenicity must be compared to demonstrate the bio-similarities of recombinant human insulin and insulin analogues.
Irina A. Proskurina, Alexander Y. Mayorov, Dmitriy V. Gorachev, Natalya D. Bunyatyan   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Insulin degludec

Journal of Mahatma Gandhi Institute of Medical Sciences, 2013
Insulin analogues have revolutionized the treatment of diabetes mellitus, and the advent of newer insulin analogues have provided better glycemic control with lesser incidence of hypoglycemia.
Vishakha V Jain, Omprakash Gupta
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Assessment of efficiency of application of various analogues of insulin in treatment of diabetes type 2 [PDF]

Саратовский научно-медицинский журнал, 2014
Purpose: to estimate efficiency of treatment of analogues of insulin Glargin and insulin Detemir in patients with diabetes type 2. Material and methods.
Rodionova T.l., Orlova M.M.
doaj