Results 61 to 70 of about 411,617 (199)

Better glycaemic control with once-weekly insulin icodec versus once-daily insulin degludec in adults with insulin-naive type 2 diabetes (ONWARDS 3)

open access: yes, 2023
International audienceBackground and aims: Efficacy and safety of once-weekly insulin icodec (icodec) versus once-daily insulin degludec (degludec) in adults with insulin-naïve type 2 diabetes were examined in ONWARDS 3, a 26-week, randomised, double ...
Desouza, C.   +8 more
core   +1 more source

The Clinical Role of Insulin Degludec/Insulin Aspart in Type 2 Diabetes: An Empirical Perspective from Experience in Australia [PDF]

open access: yes, 2020
Treatment intensification in people with type 2 diabetes following failure of basal insulin commonly involves the addition of a rapid-acting insulin analogue (basal plus one or more prandial doses; multiple daily injections) or by a switch to premixed ...
MacIsaac, RJ   +6 more
core   +1 more source

Liver Fat Changes in Patients With Type 2 Diabetes by Presence of Genetic Hepatic Steatosis: A Post Hoc Analysis of SURPASS‐3 MRI

open access: yesLiver International, Volume 46, Issue 9, September 2026.
ABSTRACT The patatin‐like phospholipase 3 (PNPLA3) I148M genetic variant is highly associated with steatotic liver disease. In the SURPASS‐3 MRI substudy, tirzepatide significantly reduced liver fat content (LFC) versus insulin degludec in insulin‐naïve patients with type 2 diabetes with metabolic dysfunction‐associated steatotic liver disease.
Kenneth Cusi   +5 more
wiley   +1 more source

Long-term safety and efficacy of insulin degludec in the management of type 2 diabetes

open access: yes, 2015
Philippe Thuillier,1 Zarrin Alavi,2 Véronique Kerlan1 1Department of Endocrinology, Diabetology and Metabolic Diseases, 2French Institute of Health and Medical Research CIC 1412, Medical University Hospital of Brest La Cavale Blanche, Brest ...
Kerlan V, Thuillier P, Alavi Z
core  

Pregnancy outcomes in women with type 1 diabetes using insulin degludec

open access: yes, 2022
Aims: To evaluate pregnancy outcomes in a real-world setting of pregnant women with type 1 diabetes using the ultra-long-acting insulin analog degludec compared to other long-acting insulin analogs throughout pregnancy.
Damm, Peter   +3 more
core   +1 more source

Is insulin degludec a more effective treatment for patients using high doses of insulin glargine but not attaining euglycemia? Some case reports from India

open access: yesDiabetes, Metabolic Syndrome and Obesity, 2014
Binayak Sinha,1 Kalyan Kumar Gangopadhyay,2 Samit Ghosal31Department of Endocrinology, AMRI Hospital, 2Department of Endocrinology, Fortis and Peerless Hospital, 3Nightingale Hospital, Kolkata, IndiaAbstract: Insulin therapy is not without side effects ...
Sinha B, Gangopadhyay KK, Ghosal S
doaj  

A FAERS database study on visual impairment adverse events associated with three long-acting insulin analogues

open access: yesFrontiers in Endocrinology
PurposeTo utilize the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) to systematically evaluate and compare the risk signals, clinical characteristics, and potential influencing factors of visual impairment adverse events (AEs ...
Li Zhong   +4 more
doaj   +1 more source

Incidental Colonic Pneumatosis Intestinalis With Pneumoperitoneum Managed Conservatively

open access: yesClinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Pneumoperitoneum accompanying pneumatosis intestinalis can mimic intestinal perforation but does not always require surgery. In asymptomatic, hemodynamically stable patients without high‐risk CT features, conservative management with careful observation and medication review may help avoid unnecessary laparotomy.
Takuya Omura, Tsukasa Aritake
wiley   +1 more source

Ligand-Controlled Assembly of Hexamers, Dihexamers, and Linear Multihexamer Structures by the Engineered Acylated Insulin Degludec

open access: yes, 2016
Insulin degludec, an engineered acylated insulin, was recently reported to form a soluble depot after subcutaneous injection with a subsequent slow release of insulin and an ultralong glucose-lowering effect in excess of 40 h in humans.
Svend Havelund (2002834)   +7 more
core   +1 more source

Glargine and degludec: Solution behaviour of higher dose synthetic insulins

open access: yesScientific Reports, 2017
Single, double and triple doses of the synthetic insulins glargine and degludec currently used in patient therapy are characterised using macromolecular hydrodynamic techniques (dynamic light scattering and analytical ultracentrifugation) in an attempt ...
Gary G. Adams   +10 more
doaj   +1 more source

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