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Comparison between basal insulin glargine and NPH insulin in patients with diabetes type 1 on conventional intensive insulin therapy [PDF]

Vojnosanitetski Pregled, 2007
Background/Aim. Insulin glargine is a long-acting insulin analog that mimics normal basal insulin secretion without pronounced peaks. The aim of this study was to compare insulin glargine with isophane insulin (NPH insulin) for basal insulin supply in ...
Pešić Milica, Živić Saša, Radenković Saša, Velojić Milena, Dimić Dragan, Antić Slobodan   +5 more
doaj   +3 more sources

Insulin glargine: pharmacokinetic and pharmacodynamic basis of clinical effect [PDF]

Сахарный диабет, 2014
Glargine became the first long-acting insulin analogue. Glargine was designed to meet basal insulin requirements throughout the day with a single injection.
Vadim Valer'evich Klimontov, Natalya Evgen'evna Myakina   +1 more
doaj   +2 more sources

Efficient Extracellular Production of Insulin Glargine in Trichoderma reesei by an Integrative Secretion‐Based Strategy [PDF]

Microbial Biotechnology
Insulin glargine, a long‐acting insulin analog, is essential for diabetes treatment. However, its industrial production remains challenging due to limitations in conventional expression systems.
Aiqin Yan, Xihai Li, Di Zhang, Lunbo Li, Jinfeng Liu, Xuejian Si, Kewen Li, Qingmin Luan, Hong Liu, Yaohua Zhong   +9 more
doaj   +2 more sources

Adverse drug events associated with insulin glargine: a real-world pharmacovigilance study based on the FAERS database [PDF]

Frontiers in Pharmacology
BackgroundInsulin glargine is a long-acting drug and the first synthetic insulin to mimic human metabolism. The safety of insulin glargine in the real world remains to be further investigated.
Tongtong Wang, Tongtong Wang, Gefei He, Gefei He, Wan Xiong, Wan Xiong, Juanjuan Huang, Juanjuan Huang   +7 more
doaj   +2 more sources

Cloning and Extracellular Expression of Glargine in Pichia pastoris

Hayati Journal of Biosciences, 2023
Patients with diabetes mellitus increase significantly every year. The increasing number of people with diabetes mellitus results in increased insulin requirements.
Dudi Hardianto, Efrida Martius, Tina Rostinawati, Anna Safarrida, Juwartina Ida Royani, Fahroziah Assyifa, Dihan Laziba   +6 more
doaj   +1 more source

Insulin glargine and cancer risk in patients with diabetes: a meta-analysis. [PDF]

PLoS ONE, 2012
AimThe role of insulin glargine as a risk factor for cancer is controversial in human studies. The aim of this meta-analysis was to evaluate the relationship between insulin glargine and cancer incidence.MethodsAll observational studies and randomized ...
Xulei Tang, Lin Yang, Zhiyu He, Jingfang Liu   +3 more
doaj   +1 more source

In vitro metabolic and mitogenic signaling of insulin glargine and its metabolites. [PDF]

PLoS ONE, 2010
BACKGROUND: Insulin glargine (Lantus) is a long-acting basal insulin analog that demonstrates effective day-long glycemic control and a lower incidence of hypoglycemia than NPH insulin.
Mark R Sommerfeld, Günter Müller, Georg Tschank, Gerhard Seipke, Paul Habermann, Roland Kurrle, Norbert Tennagels   +6 more
doaj   +1 more source

Long-acting insulin analogue in the treatment of type 2 diabetes mellitus: emphasis on proven efficacy and safety

Медицинский совет, 2021
In time, prescription of insulin therapy (IT) becomes inevitable for many patients with type 2 diabetes mellitus (DM) to achieve and maintain the target hypoglycemic range.According to the current guidelines, the addition of basal insulin to glucose ...
E. V. Biryukova, M. V. Shinkin, O. M. Mikheeva   +2 more
doaj   +1 more source

ANALISIS EFEKTIVITAS BIAYA MEDIS LANGSUNG PENGGUNAAN INSULIN DAN INSULIN KOMBINASI OHO PADA PASIEN DM TIPE 2 RAWAT JALAN DI RSUP SANGLAH DENPASAR

Jurnal Ilmiah Medicamento, 2018
Diabetes Melitus merupakan penyakit kronis dimana terapi pengobatannya dilakukan seumur hidup dan membutuhkan biaya yang sangat besar. Bervariasinya penggunaan terapi insulin atau kombinasi insulin dengan OHO (Obat Hipoglikemik Oral) pada pasien DM tipe
Ni Nyoman Wahyu Udayani, Herleeyana Meriyani, I Gusti Agung Ayu Kusuma Wardani   +2 more
doaj   +5 more sources

Physicochemical and functional characterization of MYL-1501D, a proposed biosimilar to insulin glargine.

PLoS ONE, 2021
Insulin glargine is a long-acting analogue of human insulin that has been used to manage hyperglycemia in patients with diabetes mellitus (DM) for nearly 20 years.
Parag Goyal, Harish Venkatraman Pai, Phanichand Kodali, Bhavesh Vats, Navratna Vajpai, Shankara Annegowda, Krishnappa Mane, Shamini Mohan, Shruti Saxena, Anil Bangalore Veerabhadraia, Milee Palande, Preethy Sasankan Nair, Digvijay Chandrashekar More, Umamaheshwara Rao Karudumpa, Kunala Jyothirmai, Adroha Bhattacharya, Frida Almeida, Santosh Gulab Khyade, Shankara Gouda, Daniel J Ranayhossaini, Praveen Reddy Moole, Jeffrey P Smith, Abhijit Barve, Ramakrishnan Melarkode, Rajesh Ullanat   +24 more
doaj   +1 more source