Results 231 to 240 of about 18,695,385 (300)

One‐Step Induction of Oogonia‐Like and Pro‐Spermatogonia‐Like Cells From Porcine Pluripotent Stem Cells

Advanced Science, EarlyView.
This study established a one‐step method inducing pro‐spermatogonia‐like (activating SOX17) and oogonia‐like (activating SOX17/TFAP2C) cells from porcine pgEpiSCs with a NANOS3‐tdTomato reporter. EGF activates the core PGC program and supports survival; BMP4 further induces NANOS3 and DDX4 expression; IWR1 enhances PGCLC efficiency by suppressing ...
Pengcheng He, Liang Zhong, Tianzhi Chen, Yaxuan Yan, Xinze Chen, Runbo Li, Yingjie Wang, Yadi Teng, Minglei Zhi, Meng Wang, Jinying Zhang, Fan Zhao, Dengfeng Gao, Suying Cao, Jianyong Han   +14 more
wiley   +1 more source

A New Highly Concentrated Insulin Aspart AT278 (500 U/mL) Demonstrates Ultra-Rapid Pharmacokinetic and Pharmacodynamic Properties in Type 2 Diabetes Regardless of BMI. [PDF]

Diabetes Obes Metab
Svehlikova E, Gatschelhofer C, Lackner B, Ratzer M, Fluhr G, Stoisser A, Kolaric G, Gerring D, Howell S, Jezek J, Lawrence F, Pieber TR.   +11 more
europepmc   +1 more source

Hepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O‐GlcNAcylation‐Induced m6A Demethylation of HRAS

Advanced Science, EarlyView.
Lipid stress drives O‐GlcNAcylation of the m6A demethylase FTO at Ser195, enhancing its stability and demethylase activity. This modification removes m6A from HRAS mRNA, preventing its degradation and activating PI3K/AKT signaling to promote hepatic steatosis and inflammation.
Jia‐Xin Yin, Yan‐Lai Zhang, Qun Liu, Rui Liu, Hai‐Yang Yuan, Sui‐Dan Chen, Ming‐Hua Zheng, Kai Wang, Ni Tang, Ai‐Long Huang   +9 more
wiley   +1 more source

Pretreatment TyG-BMI predicts CD19 CAR-T persistence and prognosis in diffuse large B-cell lymphoma. [PDF]

Front Oncol
Liu Z, Yang R, Chen J, Liu Z, Ding Y, Huang K, Liao Y, Hu L, Pu L, Liu L, Wang J, Tao Q, Xiong S.   +12 more
europepmc   +1 more source

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao, Long He, Yu Lu, Zanglong Deng, Hongzhen Wei, Yunpeng Zhang, Ming Yang, Tao Yin   +7 more
wiley   +1 more source

Single-cell profiling identifies obesity-disrupted brain glucose sensing. [PDF]

Nat Commun
Brown JM, Bentsen MA, Jørgensen AM, Nielsen TS, Belmont-Rausch DM, Selmanovic D, Dmytriyeva O, Kruse CH, Aalling NN, Schwalbe DC, Knights Møller O, Campbell JN, Secher A, Schwartz MW, Pers TH.   +14 more
europepmc   +1 more source

Morning Elevation in Insulin Enhances Afternoon Hepatic Glucose Disposal in Dogs by Increasing Both Insulin Signaling and Glucose Action. [PDF]

Diabetes
Waterman HL, Smith MS, Farmer B, Yankey K, Howard T, Kraft G, Cherrington AD, Edgerton DS.   +7 more
europepmc   +1 more source

Polyvinyl chloride-related insulin adsorption in critical care: a narrative review with implications for patient safety and green hospital reform. [PDF]

Front Med (Lausanne)
Elgazzar SH, Ibrahim RK, Ayoub YM, Alanazi R, Alanazi AK, Tantawi HR, Al-Qudimat AR, Alsharidah A, Hendy A.   +8 more
europepmc   +1 more source

Nose-to-Brain Therapeutics in Parkinson's Disease: Clinical Trials, Mechanisms, and Therapeutic Potential. [PDF]

Pharmaceutics
Cherny E, Minko T.
europepmc   +1 more source