Results 41 to 50 of about 18,695,385 (300)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Perioperative glycemic control in patients with coronary artery disease and diabetes mellitus type 2 undergoing coronary artery bypass grafting: results of pilot study

Сахарный диабет, 2020
BACKGROUND: According to different studies, diabetes mellitus type 2 (DM2) is associated with higher mortality after undergoing coronary artery bypass grafting (CABG).
Elena Z. Golukhova, Naida I. Bulaeva, Liubov S. Lifanova, Yaroslava V. Pugovkina   +3 more
doaj   +1 more source

Can the AHCL System Be Used in T1D Patients with Borderline TDDI? A Case Report

Sensors, 2021
(1) Background: Intensive insulin therapy using continuous subcutaneous insulin infusion (CSII) with continuous real-time glucose monitoring (rt CGM) is the best option for patients with T1D. The recent introduction of a technology called Advanced Hybrid
Anna Tekielak, Sebastian Seget, Ewa Rusak, Przemysława Jarosz-Chobot   +3 more
doaj   +1 more source

A reduction in severe hypoglycaemia in type 1 diabetes in a randomized crossover study of continuous intraperitoneal compared with subcutaneous insulin infusion

, 2009
Continuous intraperitoneal insulin infusion (CIPII) with the DiaPort system using regular insulin was compared to continuous subcutaneous insulin infusion (CSII) using insulin Lispro, to investigate the frequency of hypoglycemia, blood glucose control ...
Geelhoed-Duijvestijn, P H L M, Hoogma, R, Frei, T., Renard, E., Klein, E., Diglas, J, Kessler, L, Hoogma, R., Kessler, L., Melki, V., Klein, E, Brun, J.-M., Renseigné, Non, Diglas, J., Liebl, A, Frei, T, Schaepelynck-Bélicar, P., Liebl, A., Geelhoed-Duijvestijn, P. H. L. M., Renard, E, Diem, P., Diem, P, Brun, J-M, Schaepelynck-Bélicar, P, Melki, V, Diem, Peter, R. Hoogma, V. Melki, P. Schaepelynck-Bélicar, L. Kessler, A. Liebl, P. Diem, P. H. L. M. Geelhoed-Duijvestijn, J.-M. Brun, E. Klein, E. Renard, null null, T. Frei, J. Diglas   +38 more
core   +1 more source

Evaluation of regular insulin adsorption to polypropylene bag and polyvinyl chloride infusion set

, 2020
Aim Clinical application of insulin infusion therapy is usually accomplished with regular human insulin. It is known that the regular insulin adsorbed to the hydrophobic surfaces and different approaches were implemented into the clinical practices.
Firat, Ahmet, NENNİ, MERVE, Demirkan, Kutay, ÖZCENGİZ, DİLEK, SÜRMELİOĞLU, NURSEL, Nursel Sürmelioğlu, Kutay Demirkan, Merve Nenni, Ahmet Fırat, Dilek Özcengiz   +9 more
core   +1 more source

Management and efficacy of intensified insulin therapy starting in outpatients [PDF]

, 1989
Diabetic patients under multiple injection insulin therapy (i.e., intensified insulin therapy, IIT) usually start this treatment during hospitalization. We report here on the logistics, efficacy, and safety of IIT, started in outpatients.
Winkelmann, W., W. Hummerich, M. Steffen, B. Allolio, Allolio, B., G. Ollenschläger, W. Winkelmann, M. Reincke, Hummerich, W., Steffen, M., Ollenschläger, G., Reincke, Martin   +11 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Dual-Hormone Insulin-and-Pramlintide Artificial Pancreas for Type 1 Diabetes: A Systematic Review

Applied Sciences, 2022
The artificial pancreas (AP) is equipped with a glucose monitoring sensor, an insulin pump and an integrated mathematical algorithm that determines insulin infusion based on the glucose levels detected by the sensor.
Alezandra Torres-Castaño, Amado Rivero-Santana, Lilisbeth Perestelo-Pérez, Andrea Duarte-Díaz, Analia Abt-Sacks, Vanesa Ramos-García, Yolanda Álvarez-Pérez, Ana M. Wäagner, Mercedes Rigla, Pedro Serrano-Aguilar   +9 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Estimation of insulin sensitivity from continuous glucose monitoring and insulin pump data in type 1 diabetes [PDF]

, 2012
Diabetes mellitus is a disease characterized by chronic hyperglycemia either due to a lack of secretion of the hormone insulin (Type 1 Diabetes Mellitus, T1DM) or due to impaired action of this hormone (Type 2 Diabetes Mellitus, T2DM).
Ronca, Gabriele
core