Results 171 to 180 of about 242,514 (346)

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Inpatient Use of Automated Insulin Delivery Systems. [PDF]

J Diabetes Sci Technol
Chadalawada L, Parab R, Feeley JM, Hughes MS, Pasquel FJ, Davis GM.   +5 more
europepmc   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Patient-specific deep offline artificial pancreas for blood glucose regulation in type 1 diabetes. [PDF]

Smart Health (Amst)
Deng Y, Arao K, Mantzoros CS, Karniadakis GE.   +3 more
europepmc   +1 more source

We Need More Research and Better Designs for Insulin Infusion Sets

Journal of Diabetes Science and Technology, 2014
L. Heinemann, John Walsh, Ruth Roberts
semanticscholar   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

The use of diabetes technology under aviation conditions: A systematic review of human and in-vitro studies and future considerations. [PDF]

Diabet Med
Meçani R, Muka T, Cigler M, Basta S, El-Hakouni O, Baumann PM, Sanchez D, Olsen MT, Mathieu C, Pieber TR, Koehler G, Mader JK.   +11 more
europepmc   +1 more source

Segmental pancreatic allotransplantation in type I diabetics [PDF]

, 1984
Burg, D., Castro, L. A., Illner, Wolf-Dieter, Kampik, Anselm, Land, Walter, Landgraf, R., Landgraf-Leurs, M. M. C., Witzgall, H.   +7 more
core   +1 more source

Sulfakinin Signaling Sense Circulating Fructose and Suppresses Food Consumption via Insulin‐Like Peptide in Bactrocera Dorsalis

Advanced Science, EarlyView.
This study discovered a new pathway that tells fruit flies when to stop eating. It found that rising blood sugar (fructose) is detected by a sensor called GR43a. This triggers a chain reaction involving the satiety signal sulfakinin and its receptor, ultimately activating a final satiety signal, ILP5.
Hong‐Fei Li, Bao Dong, Zheng‐Lin Ren, Xue‐Guang Zhu, Quan Lei, Yoonseong Park, Jin‐Jun Wang, Hong‐Bo Jiang   +7 more
wiley   +1 more source

Performance of an Automated Insulin Delivery System in Youth With Type 1 Diabetes During a Diabetes Summer Camp. [PDF]

J Diabetes Sci Technol
Sotiriou G, Kavoura E, Moutafi M, Dimitriadou M, Nemtsa A, Pappa K, Christoforidis A.   +6 more
europepmc   +1 more source