Results 151 to 160 of about 9,494,626 (300)

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

Advanced Science, EarlyView.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du, Liping Wang, Sujing Diao, Juan Li, Lei Zhao, Yan Yan, Haimin Li, Weiren Dong, Wei Wu, Jinyan Gu, Jiyong Zhou   +10 more
wiley   +1 more source

Real-World safety, patient-reported outcomes, and glycemic metrics with a 7-Day extended infusion set in adults with Type 1 diabetes using automated insulin delivery systems. [PDF]

Endocrine
Nieto de la Marca MO, Fernández Velasco P, Del Amo Simón S, Sánchez Ibáñez M, Collantes Matallana A, Gómez Hoyos E, Torres Torres B, Ortolá Buigues A, de Luis Román DA, Díaz Soto G.   +9 more
europepmc   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Comparitive Study of Hormonal Counterregulation during GCIIS-Guided Insulin Hypoglycemia Tests using Human Insulin (Recombinant DNA) and Pork Insulin [PDF]

, 1985
Bekemeyer, U., Wood, W. G., Tybussek, R., Müller-Esch, G., Lühe, C. von der, Kraas, E., Ball, P., Scriba, Peter Christian, Heidbüchel, K.   +8 more
core   +1 more source

Glucose-Insulin-Potassium Therapy Guided by a Glucose-Controlled Insulin Infusion System in Acute Myocardinal Infarction [PDF]

, 1985
Bekemeyer, U., Wood, W. G., Hauptmann, A., Tybussek, R., Müller-Esch, G., Osswald, P. M., Ball, P., Djonlagic, H., Peters, A., Peters, Achim, Scriba, Peter Christian, Heidbüchel, K.   +11 more
core   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Infusion-Site MSSA as the Source of Confirmed Toxic Shock Syndrome in a 9-Year-Old on Automated Insulin Delivery System: A Case Report. [PDF]

Case Rep Pediatr
Rotondo F, Siena S, De Meco C, Maccarone P, Mansueto M, Pastore MR, Rutigliano I.   +6 more
europepmc   +1 more source

Clinical evaluation of decision support system for insulin-dose adjustment in IDDM [PDF]

, 1991
Rübsamen, M., Look, D., Jacob, U., Peters, A., Peters, Achim, Scriba, Peter Christian   +5 more
core   +1 more source

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source

Variability in Intravenous Insulin Infusion Management in Italian Intensive Care Units: A National Cross-Sectional Survey of Reported Nursing Practice. [PDF]

Nurs Crit Care
Pujia C, Neri G, Mastrangelo H, Mazza G, Biamonte E, Mercuri C, Bosco V, Montalcini T, Garofalo E.   +8 more
europepmc   +1 more source