Results 171 to 180 of about 87,132 (309)

Patient-specific deep offline artificial pancreas for blood glucose regulation in type 1 diabetes. [PDF]

Smart Health (Amst)
Deng Y, Arao K, Mantzoros CS, Karniadakis GE.   +3 more
europepmc   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

The use of diabetes technology under aviation conditions: A systematic review of human and in-vitro studies and future considerations. [PDF]

Diabet Med
Meçani R, Muka T, Cigler M, Basta S, El-Hakouni O, Baumann PM, Sanchez D, Olsen MT, Mathieu C, Pieber TR, Koehler G, Mader JK.   +11 more
europepmc   +1 more source

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

Performance of an Automated Insulin Delivery System in Youth With Type 1 Diabetes During a Diabetes Summer Camp. [PDF]

J Diabetes Sci Technol
Sotiriou G, Kavoura E, Moutafi M, Dimitriadou M, Nemtsa A, Pappa K, Christoforidis A.   +6 more
europepmc   +1 more source

Hepatotrophic effect of insulin [PDF]

, 1987
Francavilla, A, Starzl, TE
core  

Polymer Matrix‐Based 3D Culture Significantly Enhances the Differentiation and Immunomodulatory Functions of Human Adipose‐Derived Stem Cells

Advanced Science, EarlyView.
The 3D culture of human adipose‐derived stem cells (hADSCs) on a crosslinked cyclosiloxane‐based poly‐Z matrix platform enables the formation of spheroid structures enriched with extracellular matrix (ECM). These ECM‐enriched hADSC spheroids cultured on poly‐Z exhibit enhanced differentiation potential, immunomodulatory capacity, and in vivo ...
Changjin Seo, Dohyeon Kim, Junhyuk Song, Sun‐Young Kim, Youngju Son, Afia Tasnim Rahman, Sangyong Jon   +6 more
wiley   +1 more source

Safety, Feasibility, and User Experience of Automated Insulin Delivery Systems During Hajj (Muslim Pilgrimage). [PDF]

J Clin Med
Al-Sofiani ME.
europepmc   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Double Dummy Design for Blinding Studies With Automated Insulin Delivery Systems: A Proof of Concept Trial. [PDF]

J Diabetes Sci Technol
Tirosh A, Benedetti A, Peltz-Sinvani N, Laron-Hirsh M, Cohen Y, Jabarin A, Grosman B, Cohen O.   +7 more
europepmc   +1 more source