Results 111 to 120 of about 3,242,962 (243)

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Managing Severe Hypoglycaemia in Patients with Diabetes: Current Challenges and Emerging Therapies

Diabetes, Metabolic Syndrome and Obesity, 2023
Huseyin Demirbilek,1 Dogus Vuralli,1 Basma Haris,2 Khalid Hussain2 1Department of Pediatric Endocrinology, Hacettepe University Faculty of Medicine, Ankara, Turkey; 2Department of Pediatric Endocrinology, Sidra Medicine, Doha, QatarCorrespondence: Khalid
Demirbilek H, Vuralli D, Haris B, Hussain K   +3 more
doaj  

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Carbohydrate‐Mediated Cellular Uptake of Boronic Acid Hybrids In Cellulo and Insulin‐Deficient Zebrafish: Live Imaging and Application of Multiphoton FLIM

Advanced Science, EarlyView.
Boronic acid‐based fluorescent hybrids have been used as part of a versatile platform for real‐time metabolic bioimaging across cellular and organismal scales. Including glucose‐responsive imaging in living cells and in an insulin‐deficient vertebrate model, this work opens new opportunities for the development of precision diagnostics, metabolic ...
Haobo Ge, John S. Fossey, David Gonzalez Calatayud, Stephen E. Flower, Sabrina Wang, Hanna Aitessaid, Melita Tvardauskaite, Julia Dudzic, Max Jewell, Charareh Pourzand, Stanley W. Botchway, David Gurevich, Tony D. James, Sofia I. Pascu   +13 more
wiley   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Functional Fashion: Childrenswear for Insulin Pump Therapy [PDF]

, 2018
The purpose of this project was to produce a childrenswear line that addresses the wants and needs of clothing worn by diabetic children using insulin pump therapy.
Esquivias, Madelynn
core   +2 more sources

PUMP FAILURE AND MALFUNCTIONS IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES IN INSULIN PUMP THERAPY: AN ITALIAN PROSPECTIVE STUDY

, 2016
Background and Aim: Current literature regarding insulin pump-associated adverse events including pump malfunction, infusion set/site issues is discussed.
Scaramuzza A. E., Cherubini V., Pistorio A, Frongia A. P., Rabbone I, Ignaccolo G., Minuto N., Lombardo F., Bonfanti R, Marigliano M, Cherubini V, Iafusco D., Lombardo F, Iafusco D, Bonfanti R., Minuto N, Ignaccolo G, P. F. Diabetes Study Group of ISPED, Frongia AP, Toni S, Scaramuzza AE, Marigliano M., Toni S., Rabbone I., Pistorio A.   +24 more
core  

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source

Modeling and Simulation of Insulin Pump Set Failures Based on the Power Flow Method

IEEE Access
The insulin pump is a critical device for intensive insulin therapy in diabetic patients. Failures in insulin pump sets such as blockage and leakage can disrupt normal insulin delivery, potentially causing hyperglycemia or life-threatening diabetic ...
Weijie Wang, Dinghui Guo, Long Quan, Shiwei Liu   +3 more
doaj   +1 more source