Results 81 to 90 of about 3,242,962 (243)
Сахарный диабетBACKGROUND: The increase in the incidence of diabetes mellitus, including type 1 diabetes in children, is a priority issue for the national healthcare system.
E. S. Demina +5 more
doaj +1 more source
Advanced Science, EarlyView.The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo +20 more
wiley +1 more source
Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV
Advanced Science, EarlyView.Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes +14 more
wiley +1 more source
Tubed or tubeless insulin pumps? A retrospective real-world analysis of national French health data
BMJ Open Diabetes Research & CareBackground Tubeless insulin pumps, introduced in France in 2016, have been associated with higher user satisfaction than tubed pumps, primarily due to reduced interference with daily tasks. Whether this translates to greater treatment persistence remains
Bogdan Catargi +5 more
doaj +1 more source
Comparing “hybrid closed loop” artificial pancreas therapy to multi daily injection, insulin pump without CGM and insulin pump with CGM in partially open loop therapies for diabetes type-1 patients [PDF]
, 2021 Background and Aims. This study will prove that diabetes T1 therapy by means of artificial pancreas consisting on insulin pump with CGM and hybrid close loop control algorithm trained with machine learning technology provides better glycemia control than
Peiro, Joan Carles
core
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
Attitudes and habits of patients with type 1 diabetes during fasting Ramadan
Journal of Clinical & Translational Endocrinology, 2018 Objective: Fasting Ramadan is associated with changes in lifestyle patterns of patients with diabetes who choose to perform fasting. We aimed to determine the attitude and habits of patients with type 1 diabetes during fasting Ramadan. Methods: The study
Reem Alamoudi +6 more
doaj +1 more source
Advanced Science, EarlyView.This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang +11 more
wiley +1 more source
Journal of DiabetesAims It is not clear whether there are differences in glycemic control between the Equil patch and the MMT‐712 insulin pump. Our objective was to compare two types of insulin pumps in the treatment of type 2 diabetes mellitus (T2DM), using continuous ...
Yu‐Jiao Li +4 more
doaj +1 more source
Advanced Science, EarlyView.A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen +15 more
wiley +1 more source