Results 211 to 220 of about 951,131 (359)

Additive effects of obesity, hypertension, and type 2 diabetes on insulin resistance. [PDF]

, 1994
Pierre Maheux, Jørgen Jeppesen, Wayne Huey‐Herng Sheu, C.B. Hollenbeck, Cynthia Clinkingbeard, Michael S. Greenfield, Y D Chen, Gerald M. Reaven   +7 more
openalex   +1 more source

Closed‐Loop Bioelectronic Artificial Pancreas Patch for Continuous Monitoring and Regulation of Blood Glucose in Diabetic Rats and Pigs

Advanced Science, EarlyView.
A closed‐loop bioelectronic artificial pancreas patch is presented for glucose monitoring and regulation. Utilizing transiently dissolvable microneedle arrays integrated with microtube arrays, the patch efficiently delivers insulin into interstitial fluid, eliminating the need for external long needles. In diabetic pigs, it demonstrates excellent blood
Yiqun Liu, Changxi Zhang, Lingyi Xu, Yuan Ma, Yuanyuan Ma, Ying Chen, Difei Lu, Le Ye, Li Yang, Yue Cui   +9 more
wiley   +1 more source

Insulin resistance, metabolic syndrome and polycystic ovaries: an intriguing conundrum. [PDF]

Front Endocrinol (Lausanne)
Prosperi S, Chiarelli F.
europepmc   +1 more source

Insulin Resistance in Humans

, 1982
Jerrold M. Olefsky
openalex   +1 more source

Hepatic ENTPD5 Is Critical for Maintaining Metabolic Homeostasis and Promoting Brown Adipose Tissue Thermogenesis

Advanced Science, EarlyView.
ENTPD5‐mediated conversion of extracellular adenosine triphosphate to ADP of hepatocytes is critical for maintaining hepatic glucose/lipid metabolism and promoting brown adipose tissue thermogenesis via the inhibition of adrenomedullin expression and secretion.
Rufeng Ma, Song Hou, Rui Xiang, Wenjun Liu, Xin Li, Yujing Chi, Ming Xu, Haochen Yao, Jing Li, Jichun Yang   +9 more
wiley   +1 more source

Endoplasmic reticulum stress contributes to insulin resistance in Hashimoto's thyroiditis. [PDF]

Endocr Connect
Zhou Q, Zhang LY, Gao XL, Zou CC, Liu H.
europepmc   +1 more source

m6A‐Modified circRAPGEF1 Interaction with IGF2BP3 Promotes Hepatocellular Carcinoma Progression via Reprogramming Aspartate Metabolism

Advanced Science, EarlyView.
In hepatocellular carcinoma (HCC), the m6A‐modified circRAPGEF1 destabilizes ASS1 mRNA via competitive binding to IGF2BP3, driving aspartate metabolic reprogramming in liver cancer stem cells (LCSCs). This cascade enhances stemness properties and reduces sorafenib sensitivity in LCSCs, thereby identifying circRAPGEF1 as a promising therapeutic target ...
Juanyi Shi, Sintim Mui, Yongcong Yan, Shaomin Liu, Kai Wen, Chuanchao He, Huoming Li, Hao Liao, Meng Tao, Jiahua Wen, Weidong Wang, Xiaoding Xu, Zhenyu Zhou, Zhiyu Xiao   +13 more
wiley   +1 more source

Evaluating indices of insulin resistance and estimating the prevalence of insulin resistance in a large biobank cohort. [PDF]

Front Endocrinol (Lausanne)
Aliyu U, Toor SM, Abdalhakam I, Elrayess MA, Abou Samra AB, Albagha OME.   +5 more
europepmc   +1 more source

HLA-DQA1*1 contributes to resistance and A1*3 confers susceptibility to Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects [PDF]

, 1991
Kazuya Yamagata, Toshiaki Hanafusa, Hideaki Nakajima, M. Sada, Hiroshi Amemiya, Tamio Noguchi, T Tanaka, Norio Kôno, S Tarui   +8 more
openalex   +1 more source

Optimized Monothiol Thioredoxin Derivative (ORP100S) Protects In Vitro and In Vivo from Radiation and Chemotoxicity Without Promoting Tumor Proliferation

Advanced Science, EarlyView.
Native thioredoxin‐1 (TRX) stimulates proliferation and rescues stem cells and cancer cells from multiple stressors by suppressing p53 and inhibiting ferroptosis via GPX4/SLC7A11 upregulation mediated by enhanced KLF4 expression and p53 promoter binding.
Jian Wu, Xiaobei Wang, Parker Mathews, Shaima Jabbar, Min Zhang, Haim Moskowitz, Wei Duan, David P. Nichols, George William Schaaf, John D. Olson, Andrew N. Macintyre, J. Daniel Bourland, Ivan Spasojevic, Jen‐Tsan Ashley Chi, Joel Ross, Nelson Chao, J. Mark Cline, Peter B. Heifetz, Yubin Kang   +18 more
wiley   +1 more source