Results 301 to 310 of about 3,853,066 (390)

Insulin resistance-induced mitochondrial dysfunction and pyroptosis in trophoblasts: protective role of metformin. [PDF]

BMC Pregnancy Childbirth
Du R, Bai Y, Li L, Shao Y, Wu N.
europepmc   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

Deoxycholic acid ameliorates obesity and insulin resistance by enhancing lipolysis and thermogenesis. [PDF]

Lipids Health Dis
Tuerhongjiang G, Li Y, Meng Z, Gao X, Wei Y, Muhetaer G, Li P, Zhang Y, Zhang J, Wu Y, Liu J.   +10 more
europepmc   +1 more source

Gut Microbiota Colonization in Early Life Influences Susceptibility to Adulthood Hepatic Lipid Accumulation in High‐Fat‐Diet‐Fed Mice

Advanced Science, EarlyView.
This study indicates that perinatal antibiotic exposure elevates susceptibility to high‐fat‐diet‐induced hepatic lipid accumulation via disrupting early‐life gut microbiota colonization. The decreased Lactobacillus colonization inhibits primary‐to‐secondary bile acid conversion, lowering secondary bile acids, enhancing adulthood intestinal lipid ...
Yan‐Yan Zhu, Xin Dong, Hao Zhou, Ze‐Yan Li, Bo Wang, Ya‐Ping Song, Zhi‐Bing Liu, Xue Lu, Yi‐Hao Zhang, Yichao Huang, Hua Wang, De‐Xiang Xu   +11 more
wiley   +1 more source

Identification of Interactive Genetic Loci Linked to Insulin Resistance in Metabolic Syndrome-An Update. [PDF]

Medicina (Kaunas)
Elfaki I, Mir R, Elnageeb ME, Hamadi A, Alharbi ZM, Bedaiwi RI, Javid J, Alrasheed T, Alatawi D, Alrohaf BM, Abunab MK, Muqri TA.   +11 more
europepmc   +1 more source

Quercetin‐Driven Akkermansia Muciniphila Alleviates Obesity by Modulating Bile Acid Metabolism via an ILA/m6A/CYP8B1 Signaling

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Quercetin intervention reshapes the overall structure of microbiota and significantly increases the abundance of beneficial gut commensal A. muciniphila. Enrichment of A. muciniphila leads to generate more ILA to facilitate cholesterol converts to CA in FTO/m6A/CYP8B1 coordinated manner, thereby reversing obesity‐related phenotypes via activating FXR ...
Jiaqi Liu, Youhua Liu, Chaoqun Huang, Chuan He, Tongyudan Yang, Ruiti Ren, Zimeng Xin, Xinxia Wang   +7 more
wiley   +1 more source

Physical training reduces cell senescence and associated insulin resistance in skeletal muscle. [PDF]

Mol Metab
Podraza-Farhanieh A, Spinelli R, Zatterale F, Nerstedt A, Gogg S, Blüher M, Smith U.   +6 more
europepmc   +1 more source

Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD

Advanced Science, Volume 12, Issue 15, April 17, 2025.
A potent HDAC11‐specific inhibitor, B6, is identified using substrate‐mimic and bioisosteric replacement strategies. B6 demonstrates high oral bioavailability, extensive liver distribution, and a favorable safety profile. B6 effectively alleviates metabolic dysfunction‐associated steatotic liver disease by increasing the expression of LKB1 and ...
Feng Zhang, Kairui Yue, Simin Sun, Shengyuan Lu, Geng Jia, Yang Zha, Shuang Zhang, C. James Chou, Chenzhong Liao, Xiaoyang Li, Yajun Duan   +10 more
wiley   +1 more source

Insulin Resistance in an Underweight Woman with Polycystic Ovary Syndrome: A Case Study. [PDF]

Am J Case Rep
Gacaferri Lumezi B, Lokaj-Berisha V.
europepmc   +1 more source

The Metabolite Indole‐3‐Acetic Acid of Bacteroides Ovatus Improves Atherosclerosis by Restoring the Polarisation Balance of M1/M2 Macrophages and Inhibiting Inflammation

Advanced Science, Volume 12, Issue 11, March 20, 2025.
Briefly, patients with ASCVD have a reduced abundance of B. ovatus in their feces. Oral administration of live B. ovatus attenuated atherosclerosis. Specifically, B. ovatus restores the expression of intestinal barrier proteins and improves bile acid metabolism, while producing the tryptophan metabolite IAA restores the M1/M2 polarisation balance by ...
Wu Liu, Jingyu Wang, Heng Yang, Congcong Li, Wanqi Lan, Tingtao Chen, Yanhua Tang   +6 more
wiley   +1 more source