Results 311 to 320 of about 3,853,066 (390)

Transient extreme insulin resistance in a critically ill patient: A case report.

World J Clin Cases
Wei XY, Shen HN.
europepmc   +1 more source

Effect of limb ischemic preconditioning on the indirect index of insulin resistance in maintenance hemodialysis patients. [PDF]

BMC Cardiovasc Disord
Zhang Y, Tang Y, Xu L, Fang L, Li X, Mao W, Liu T.   +6 more
europepmc   +1 more source

HDAC2‐Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple‐Negative Breast Cancer

Advanced Science, Volume 12, Issue 14, April 10, 2025.
This study identifies the lactylation modification of methyltransferase‐like 3 (METTL3) in breast tumors and its delactylase histone deacetylase 2 (HDAC2). It elucidates the molecular mechanism by which HDAC2‐mediated METTL3 delactylation promotes triple‐negative breast cancer (TNBC) resistance to cisplatin through upregulation of DNA damage repair ...
Xiaoniu He, Yuanpei Li, Jian Li, Yu Li, Sijie Chen, Xia Yan, Zhangrong Xie, Jiangfeng Du, Guoan Chen, Jianbo Song, Qi Mei   +10 more
wiley   +1 more source

Fecal propionate is a signature of insulin resistance in polycystic ovary syndrome. [PDF]

Front Cell Infect Microbiol
Dong S, Yao X, Jiao J, Lin B, Yan F, Wang X.   +5 more
europepmc   +1 more source

The Type III Secretion System (T3SS) of Escherichia Coli Promotes Atherosclerosis in Type 2 Diabetes Mellitus

Advanced Science, Volume 12, Issue 15, April 17, 2025.
Large‐scale studies indicate a strong relationship between the gut microbiome, type 2 diabetes mellitus (T2DM), and atherosclerotic cardiovascular disease (ASCVD). Here, a higher abundance of the type III secretion system (T3SS) virulence factors of Enterobacteriaceae/Escherichia‐Shigella in patients with T2DM‐related‐ASCVD, which correlates with their
Yao‐Yuan Zhang, Song‐Tao Chen, Gang Chen, Le Zhou, Guo‐Liang Zhou, Xin‐Yuan Yu, Long Yuan, Wei‐Qian Deng, Zhen‐Bo Wang, Jing Li, Yi‐Fu Tu, Da‐Wei Zhang, Yuan li, Abdul Sammad, Xiao Zhu, Kai Yin   +15 more
wiley   +1 more source

Insulin Resistance Is a Modifying Factor for Parkinson's Disease. [PDF]

Mov Disord
Zagare A, Hemedan A, Almeida C, Frangenberg D, Gomez-Giro G, Antony P, Halder R, Krüger R, Glaab E, Ostaszewski M, Arena G, Schwamborn JC.   +11 more
europepmc   +1 more source

PPY‐Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma features abundant stromal components that hinder therapy efficacy. Single‐cell RNA sequencing analysis combined with experiments identified PPY, a gastrointestinal hormone, as a novel inducer of immunosuppressive iCAFs. Mechanistic studies revealed that PPY activates the non‐canonical NF‐κB pathway via EGFR.
Mengdie Cao, Wang Peng, Bin Cheng, Ronghua Wang, Wei Chen, Luyao Liu, Hai Huang, Shiru Chen, Haochen Cui, JingWen Liang, Qiaodan Zhou, Si Xiong, Shuya Bai, Luoxia Liu, Yuchong Zhao   +14 more
wiley   +1 more source

Unraveling the Mystery of Insulin Resistance: From Principle Mechanistic Insights and Consequences to Therapeutic Interventions. [PDF]

Int J Mol Sci
Mir MM, Jeelani M, Alharthi MH, Rizvi SF, Sohail SK, Wani JI, Sabah ZU, BinAfif WF, Nandi P, Alshahrani AM, Alfaifi J, Jehangir A, Mir R.   +12 more
europepmc   +1 more source

Predictability of genetic risk score for insulin resistance is influenced by both BMI and race. [PDF]

Obesity (Silver Spring)
Yurchishin ML, Fowler LA, Goss AM, Garvey WT, Gower BA.   +4 more
europepmc   +1 more source

The role of insulin resistance and APOE genotype on blood-brain barrier integrity in Alzheimer's disease. [PDF]

Alzheimers Dement
Padovani A, Galli A, Bazzoli E, Tolassi C, Caratozzolo S, Gumina B, Benussi A, Libri I, Outeiro TF, Pilotto A.   +9 more
europepmc   +1 more source