Results 331 to 340 of about 3,853,066 (390)

Hypertension and Insulin Resistance

Journal of Cardiovascular Pharmacology, 1992
Insulin resistance and hyperinsulinemia is now recognized in non-insulin-dependent diabetes, essential hypertension, obesity, atherosclerotic heart disease, dyslipidemia, heart failure, and in heavy smokers. Several mechanisms have been proposed to explain hyperinsulinemia, insulin resistance and its relationship to hypertension; reduced sodium ...
D. J. Betteridge, Brian N. C. Prichard, S. Sen, Christopher C.T. Smith   +3 more
openaire   +2 more sources

Immunologic insulin resistance

Diabetes, 1978
The efficacy of sulfated beef insulin for plasma glucose control in 35 patients with immunologie insulin resistance was studied. Patients were on a mean dose of 550 U./day (range 200–2,000) of U-500 regular beef insulin. Mean maximum 125I-insulin-binding capacity was 191 mU./ml. serum (range 13–1,080).
John K Davidson, Donald W DeBra
openaire   +2 more sources

Hexosamines and Insulin Resistance

Diabetes, 1996
Glucose is an important regulator of cell growth and metabolism. Thus, it is likely that some of the adverse effects of hyperglycemia are reflections of normal regulation by abnormal concentrations of glucose. How the cell senses glucose, however, is still incompletely understood.
Donald A. McClain, Errol D. Crook
openaire   +3 more sources

Iron and insulin resistance

Alimentary Pharmacology & Therapeutics, 2005
SummaryBackground : Preliminary clinical and experimental results suggest that iron can modify hepatocytes’ insulin sensitivity by interfering with insulin receptor and intracellular insulin signalling.Aim : To evaluate in vivo the influence of iron on insulin resistance and insulin release in patients with non‐alcoholic fatty liver disease and in ...
A. Guzzo, A.L. Fracanzani, A. Orsatti, L. Valenti, E. Fatta, S. Colombo, E. Pulixi, S. Fargion   +7 more
openaire   +5 more sources

Insulin resistance: Review of the underlying molecular mechanisms

Journal of Cellular Physiology, 2018
Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin. Insulin signaling is therefore critical for these tissues.
Habib Yaribeygi, F. R. Farrokhi, A. Butler, A. Sahebkar   +3 more
semanticscholar   +1 more source

Insulin resistance and the endothelium

Current Diabetes Reports, 2004
Type 2 diabetes is a cardiovascular disease equivalent that is associated with accelerated atherosclerosis and significant mortality. However, the metabolic syndrome and prediabetes are associated with increased cardiovascular mortality, indicating that atherogenic vascular changes begin prior to the onset of overt diabetes. At the core of diabetes and
Willa A. Hsueh, Manuel J. Quiñones, Christopher J. Lyon   +2 more
openaire   +5 more sources

Infliximab and insulin resistance

Autoimmunity Reviews, 2010
Insulin resistance is the most important pathophysiologic feature of obesity, type 2 diabetes mellitus and prediabetic states. TNF-alpha, a proinflammatory cytokine, plays a pivotal role in the pathogenesis of inflammation-associated insulin resistance during the course of rheumatic diseases.
Ursini F., Naty S., Grembiale R. D.
openaire   +3 more sources

Glucose clamp technique: a method for quantifying insulin secretion and resistance.

American Journal of Physiology, 1979
Methods for the quantification of beta-cell sensitivity to glucose (hyperglycemic clamp technique) and of tissue sensitivity to insulin (euglycemic insulin clamp technique) are described. Hyperglycemic clamp technique. The plasma glucose concentration is
R. DeFronzo, J. Tobin, R. Andres
semanticscholar   +1 more source

Glycosphingolipids and Insulin Resistance

2011
Glycosphingolipids are structural membrane components, residing largely in the plasma membrane with their sugar-moieties exposed at the cell's surface. In recent times a crucial role for glycosphingolipids in insulin resistance has been proposed. A chronic state of insulin resistance is a rapidly increasing disease condition in Western and developing ...
Aerts, J.M., Boot, R.G., van Eijk, M., Groener, J., Bijl, N., Lombardo, E., Bietrix, F.M., Dekker, N., Groen, A.K., Ottenhof, M., Roomen, C., Aten, J., Serlie, M., Langeveld, M., Wennekes, T., Overkleeft, H.S.   +15 more
openaire   +4 more sources

Banting lecture 1988. Role of insulin resistance in human disease.

Diabetes, 1988
Resistance to insulin-stimulated glucose uptake is present in the majority of patients with impaired glucose tolerance (IGT) or non-insulin-dependent diabetes mellitus (NIDDM) and in approximately 25% of nonobese individuals with normal oral glucose ...
G. Reaven
semanticscholar   +1 more source