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Insulin Receptors and Insulin Resistance
Annual Review of Medicine, 1983Resistance to the action of insulin plays a central role in many important disease states, including diabetes and obesity. Many insights into the mechanism and significance of insulin resistance in these and other disorders have followed upon our expanding knowledge regarding insulin receptors.
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Macrophages, inflammation, and insulin resistance.
Annual Review of Physiology, 2010Obesity induces an insulin-resistant state in adipose tissue, liver, and muscle and is a strong risk factor for the development of type 2 diabetes mellitus.
J. Olefsky, C. Glass
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Cardiomyopathy of Insulin Resistance
Heart Failure Clinics, 2006For many patients diagnosed with heart failure, the underlying etiology remains elusive. Up to half of heart failure cases are not the result of coronary artery disease, and most of these are deemed ‘‘idiopathic’’ in origin. A further understanding of the cause of heart failure in these individuals could lead to great improvements in prevention and ...
Michael B. Fowler, Ronald M. Witteles
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The aetiology and molecular landscape of insulin resistance
Nature reviews. Molecular cell biology, 2021D. James, J. Stöckli, M. Birnbaum
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Pathophysiology of insulin resistance
Best Practice & Research Clinical Endocrinology & Metabolism, 2006Insulin resistance is a feature of a number of clinical disorders, including type 2 diabetes/glucose intolerance, obesity, dyslipidaemia and hypertension clustering in the so-called metabolic syndrome. Insulin resistance in skeletal muscle manifests itself primarily as a reduction in insulin-stimulated glycogen synthesis due to reduced glucose ...
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Journal of Diabetes and its Complications, 2016
Sirtuin 1 (SIRT1) is a prototype mammalian NAD(+)-dependent protein deacetylase that has emerged as a key metabolic sensor in various metabolic tissues. Growing evidence suggests that SIRT1 regulates glucose and lipid metabolism through its deacetylase activity.
Xinli Jiang +5 more
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Sirtuin 1 (SIRT1) is a prototype mammalian NAD(+)-dependent protein deacetylase that has emerged as a key metabolic sensor in various metabolic tissues. Growing evidence suggests that SIRT1 regulates glucose and lipid metabolism through its deacetylase activity.
Xinli Jiang +5 more
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Acta Diabetologica Latina, 1970
Chronic insulin resistance has been defined and its clinical characteristics summarized. Although increased insulin antibodies can be demonstrated in most patients with chronic insulin resistance, there is not always a good correlation between the severity of the insulin resistance and the titer of insulin antibodies. Several insulin resistant patients
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Chronic insulin resistance has been defined and its clinical characteristics summarized. Although increased insulin antibodies can be demonstrated in most patients with chronic insulin resistance, there is not always a good correlation between the severity of the insulin resistance and the titer of insulin antibodies. Several insulin resistant patients
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Modification of Insulin Resistance
Journal of Mental Science, 1956Sakel (1938a) drew attention to the difficulty of establishing satisfactory comas in a minority of patients attending for Deep Insulin therapy. This phenomenon has since been confirmed by other workers including Tillim (1938) whose patient received 500 units of insulin without the production of deep coma, by Hall (1940) who reported an instance in ...
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American Journal of Kidney Diseases, 1989
Glucose intolerance is a nearly universal finding in patients with chronic renal failure and in animal models of uremia. The glucose intolerance results from impaired insulin-mediated glucose disposal by muscle, adipose, and liver tissue. Insulin binding by these tissues is not reduced.
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Glucose intolerance is a nearly universal finding in patients with chronic renal failure and in animal models of uremia. The glucose intolerance results from impaired insulin-mediated glucose disposal by muscle, adipose, and liver tissue. Insulin binding by these tissues is not reduced.
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