Results 351 to 360 of about 4,252,621 (405)

Hexosamines and Insulin Resistance

Diabetes, 1996
Glucose is an important regulator of cell growth and metabolism. Thus, it is likely that some of the adverse effects of hyperglycemia are reflections of normal regulation by abnormal concentrations of glucose. How the cell senses glucose, however, is still incompletely understood.
Donald A. McClain, Errol D. Crook
openaire   +3 more sources

Insulin resistance: Review of the underlying molecular mechanisms

Journal of Cellular Physiology, 2018
Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin. Insulin signaling is therefore critical for these tissues.
Habib Yaribeygi, F. R. Farrokhi, A. Butler, A. Sahebkar   +3 more
semanticscholar   +1 more source

Insulin resistance and the endothelium

Current Diabetes Reports, 2004
Type 2 diabetes is a cardiovascular disease equivalent that is associated with accelerated atherosclerosis and significant mortality. However, the metabolic syndrome and prediabetes are associated with increased cardiovascular mortality, indicating that atherogenic vascular changes begin prior to the onset of overt diabetes. At the core of diabetes and
Willa A. Hsueh, Manuel J. Quiñones, Christopher J. Lyon   +2 more
openaire   +5 more sources

Infliximab and insulin resistance

Autoimmunity Reviews, 2010
Insulin resistance is the most important pathophysiologic feature of obesity, type 2 diabetes mellitus and prediabetic states. TNF-alpha, a proinflammatory cytokine, plays a pivotal role in the pathogenesis of inflammation-associated insulin resistance during the course of rheumatic diseases.
Ursini F., Naty S., Grembiale R. D.
openaire   +3 more sources

Glucose clamp technique: a method for quantifying insulin secretion and resistance.

American Journal of Physiology, 1979
Methods for the quantification of beta-cell sensitivity to glucose (hyperglycemic clamp technique) and of tissue sensitivity to insulin (euglycemic insulin clamp technique) are described. Hyperglycemic clamp technique. The plasma glucose concentration is
R. DeFronzo, J. Tobin, R. Andres
semanticscholar   +1 more source

Glycosphingolipids and Insulin Resistance

2011
Glycosphingolipids are structural membrane components, residing largely in the plasma membrane with their sugar-moieties exposed at the cell's surface. In recent times a crucial role for glycosphingolipids in insulin resistance has been proposed. A chronic state of insulin resistance is a rapidly increasing disease condition in Western and developing ...
Aerts, J.M., Boot, R.G., van Eijk, M., Groener, J., Bijl, N., Lombardo, E., Bietrix, F.M., Dekker, N., Groen, A.K., Ottenhof, M., Roomen, C., Aten, J., Serlie, M., Langeveld, M., Wennekes, T., Overkleeft, H.S.   +15 more
openaire   +4 more sources

Insulin Receptors and Insulin Resistance

Annual Review of Medicine, 1983
Resistance to the action of insulin plays a central role in many important disease states, including diabetes and obesity. Many insights into the mechanism and significance of insulin resistance in these and other disorders have followed upon our expanding knowledge regarding insulin receptors.
openaire   +2 more sources

Banting lecture 1988. Role of insulin resistance in human disease.

Diabetes, 1988
Resistance to insulin-stimulated glucose uptake is present in the majority of patients with impaired glucose tolerance (IGT) or non-insulin-dependent diabetes mellitus (NIDDM) and in approximately 25% of nonobese individuals with normal oral glucose ...
G. Reaven
semanticscholar   +1 more source

Macrophages, inflammation, and insulin resistance.

Annual Review of Physiology, 2010
Obesity induces an insulin-resistant state in adipose tissue, liver, and muscle and is a strong risk factor for the development of type 2 diabetes mellitus.
J. Olefsky, C. Glass
semanticscholar   +1 more source

Cardiomyopathy of Insulin Resistance

Heart Failure Clinics, 2006
For many patients diagnosed with heart failure, the underlying etiology remains elusive. Up to half of heart failure cases are not the result of coronary artery disease, and most of these are deemed ‘‘idiopathic’’ in origin. A further understanding of the cause of heart failure in these individuals could lead to great improvements in prevention and ...
Michael B. Fowler, Ronald M. Witteles
openaire   +3 more sources