Results 41 to 50 of about 1,576,833 (200)

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Les fondements de la bonne gouvernance au Monténégro dans le contexte de son intégration euro-atlantique [PDF]

open access: yesSynergies Roumanie, 2019
Nous ne nous proposons pas de faire une étude historique du Monténégro, ou d’établir des parallèles visant l’obtention de son indépendance. L’expérience communiste du pays, en tant que province de la République fédérative socialiste de Yougoslavie, a ...
Adrian-Gabriel Corpădean
doaj  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The Overlay, a New Solution for Volume Variations in the Residual Limb for Individuals with a Transtibial Amputation

open access: yesSensors
Background: The company Ethnocare has developed the Overlay, a new pneumatic solution for managing volumetric variations (VVs) of the residual limb (RL) in transtibial amputees (TTAs), which improves socket fitting.
Pierre Badaire   +2 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

La perception du pouvoir métropolitain par les Européens d’Algérie

open access: yesCahiers d’histoire, 2001
Une lecture rapide des événements ayant marqué la fin de la guerre d’Algérie, notamment les affrontements entre Européens et forces de l’ordre, donne l’impression d’une rupture entre cette communauté et la métropole.
Marc-Olivier Gavois
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Les applications mobiles, un outil pour développer l’expression orale autonome des débutants en français à l’université : étude de cas [PDF]

open access: yesSynergies Espagne, 2023
L’analyse de l’usage des applications mobiles pour l’enseignement-apprentissage du français est devenue une nécessité. Celle du CAVILAM – Alliance française, nommée Français Premiers Pas, téléchargeable gratuitement, attire logiquement l’attention des
Arrate Aldama Epelde   +1 more
doaj  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

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