Advanced Science, EarlyView.This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong +6 more
wiley +1 more source
Transient Antiskyrmion‐Mediated Topological Transitions in Isotropic Magnets
Advanced Science, EarlyView.A transient antiskyrmion‐mediated pathway that drives repeated stripe‐to‐skyrmion transitions is revealed, producing a net increase in topological charge in isotropic Dzyaloshinskii–Moriya interaction films. Experiments and simulations identify the antiskyrmion as a metastable excitation, enabling stochastic bitstream generation for probabilistic ...
Bingqian Dai +18 more
wiley +1 more source
Branch and Bound Algorithm for a Discrete Multilevel Linear Fractional Programming Problem
Operations Research and Decisions, 2018 An algorithm is proposed to find an integer solution for bilevel linear fractional programming problem with discrete variables. The method develops a cut that removes the integer solutions which are not bilevel feasible.
Ritu Arora, Kavita Gupta
doaj
Single‐Target Pairing System (StarPair) for Large‐Scale Interrogation of Cell–Cell Interactions
Advanced Science, EarlyView.This work presents a single‐target pairing system, StarPair, enabling cell–cell interaction studies by target combination in droplets. StarPair offers superior pairing efficiencies over 95% and operation frequencies of 105 pairs per 9.5 h for two‐target pairing, allowing large‐scale interrogation of immune cell‐cancer cell interactions and precise ...
Tianjiao Mao +6 more
wiley +1 more source
Solving the shift and break design problem using integer linear programming [PDF]
, 2019 Arjan Akkermans +2 more
openalex +1 more source
A Clarification on Quantum‐Metric‐Induced Nonlinear Transport
Advanced Science, EarlyView.How does the quantum metric truly govern the nonlinear transport? The longstanding theoretical discrepancies are resolved in quantum‐metric‐induced nonlinear transport and the correct intrinsic nonlinear conductivity is identified. Furthermore, a toy model is engineered to suppress the competing effects, uniquely highlighting the role of quantum metric
Xiao‐Bin Qiang +4 more
wiley +1 more source
THE RAY-METHOD: THEORETICAL BACKGROUND AND COMPUTATIONAL RESULTS
Croatian Operational Research Review, 2012 In our talk we present an algorithm for determining initial bound for the Branch and Bound (B&B) method. The idea of the algorithm is based on the use of the "ray" introduced in the "ray-method" developed for solving integer programming problems [13 ...
Erik Bajalinov, Anett Rácz
doaj
Modeling Operation Problem of Micro-grids Considering Economical, Technical and Environmental issues as Mixed-Integer Non-Linear Programming [PDF]
, 2016 Samira Salahi, Salah Bahramara
openalex +1 more source
Optimal Cloud Orchestration Model of Containerized Task Scheduling Strategy Using Integer Linear Programming: Case Studies of IoTcloudServe@TEIN Project [PDF]
, 2021 Nawat Swatthong, Chaodit Aswakul
openalex +1 more source
Atomic‐Scale Insights into Yttrium‐Induced Grain Boundary Structure Modification in Al2O3
Advanced Science, EarlyView.Using advanced STEM characterization combined with NNP‐based MCMD calculations, it is revealed that Y segregation at ∑13 Al2O3 GB involves not only simple substitution of Y for Al atoms but also structural adaptation with a change in GB atomic density, leading to minimized excess volume and lowest GB energy.
Jingyuan Yan +7 more
wiley +1 more source