Results 171 to 180 of about 359,233 (279)

Phylogenetic Clustering by Linear Integer Programming (PhyCLIP). [PDF]

Mol Biol Evol, 2019
Han AX, Parker E, Scholer F, Maurer-Stroh S, Russell CA.   +4 more
europepmc   +1 more source

A Guide to Bayesian Optimization in Bioprocess Engineering

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Bayesian optimization has become widely popular across various experimental sciences due to its favorable attributes: it can handle noisy data, perform well with relatively small data sets, and provide adaptive suggestions for sequential experimentation.
Maximilian Siska, Emma Pajak, Katrin Rosenthal, Antonio del Rio Chanona, Eric von Lieres, Laura M. Helleckes   +5 more
wiley   +1 more source

Real‐time biosensing of Parkinson's disease biomarkers via NIR‐activated upconversion nanoparticles

BMEMat, EarlyView.
Schematic illustration of the luminescence resonance energy transfer‐driven core‐shell‐shell UCNPs (cssUCNPs@Fluo4) nanoprobe for simultaneous monitoring of Ca²⁺‐temperature dynamics in Parkinson's disease models. Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder with incompletely understood pathophysiology, necessitating ...
Jialin Liu, Nan Li, Yu Chen, Rui Pu, Wei Wei, Yunqi Lin, Lejing Li, Yao Lu, Jianhua Hao, Lihua Li   +9 more
wiley   +1 more source

Optimized Risk Assessment in Forensic Practice: A Comparison of Machine Learning and Manual Scoring Approaches

Behavioral Sciences &the Law, EarlyView.
ABSTRACT As correctional jurisdictions and risk instrument developers look to optimize scoring for specific population needs, an open question remains ‐ which method is optimal. Popular scoring methods range from manual simple scoring approaches (e.g., Burgess) to more complex machine learning algorithms (e.g., random forests).
Danielle J. Rieger, Ralph C. Serin, Shelley L. Brown   +2 more
wiley   +1 more source

Sequential, chromosome‐specific glutamine synthetase double knockout with Cas‐CLOVER establishes enhanced CHO platforms for cell line development

Biotechnology Progress, EarlyView.
This study established the first creation of a commercially available double GS knockout (DKO) from a single KO in CHO‐K1 cells, called CleanCut GS CHO using Cas‐CLOVER. When combined with the Harbor‐IN transposase system, CleanCut GS CHO cells demonstrated a highly antibody productivity.
Cintia Gomez Limia, Valeriya Steffey, Hsueh Che Cheng, Daniel Machado, Thomas Hart, Mark Cameron McHargue, Corey Brizzee, Jack Crawford   +7 more
wiley   +1 more source

Lifespan Pancreas Morphology for Control Versus Type 2 Diabetes Using AI on Largescale Clinical Imaging

Clinical Anatomy, EarlyView.
ABSTRACT Understanding how pancreas size and shape change with normal aging is critical for establishing a baseline to detect deviations in type 2 diabetes and other pancreatic disease. We measure pancreas size and shape using morphological measurements from early development through aging (ages 0–90).
Lucas W. Remedios, Chloe Cho, Trent M. Schwartz, Dingjie Su, Gaurav Rudravaram, Chenyu Gao, Aravind R. Krishnan, Adam M. Saunders, Michael E. Kim, Shunxing Bao, Thomas A. Lasko, Alvin C. Powers, Bennett A. Landman, John Virostko   +13 more
wiley   +1 more source

Comparative Network Reconstruction using mixed integer programming. [PDF]

Bioinformatics, 2018
Bosdriesz E, Prahallad A, Klinger B, Sieber A, Bosma A, Bernards R, Blüthgen N, Wessels LFA.   +7 more
europepmc   +1 more source

Playing with fire? A mean‐field game analysis of fire sales and systemic risk under regulatory capital constraints

Canadian Journal of Statistics, EarlyView.
Abstract We analyze the effect of regulatory capital constraints on financial stability in a large homogeneous banking system using a mean‐field game (MFG) model. Each bank holds cash and a tradable risky asset. Banks choose absolutely continuous trading rates in order to maximize expected terminal equity, with trades subject to transaction costs ...
Rüdiger Frey, Theresa Traxler
wiley   +1 more source

Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming. [PDF]

Sci Rep, 2019
Ahmed N, Sormanni P, Ciryam P, Vendruscolo M, Dobson CM, O'Brien EP.   +5 more
europepmc   +1 more source

Joint modelling of annual precipitation maxima over several durations for the construction of intensity–duration–frequency curves

Canadian Journal of Statistics, EarlyView.
Abstract Intensity–duration–frequency curves are used by a wide range of professionals to manage the risks related to extreme rainfall. In Canada, these curves are produced by Environment and Climate Change Canada on the basis of Gumbel distributions fitted independently for each accumulation period.
Paul Mathivon, Christian Genest, Jonathan Jalbert   +2 more
wiley   +1 more source