Results 41 to 50 of about 72,758 (294)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Non-integrability of the generalised spring-pendulum problem

, 2003
We investigate a generalisation of the three dimensional spring-pendulum system. The problem depends on two real parameters $(k,a)$, where $k$ is the Young modulus of the spring and $a$ describes the nonlinearity of elastic forces.
Maciejewski, Andrzej J., Przybylska, Maria, Weil, Jacques-Arthur   +2 more
core   +1 more source

Dirichlet and Neumann Problems for String Equation, Poncelet Problem and Pell-Abel Equation [PDF]

, 2006
We consider conditions for uniqueness of the solution of the Dirichlet or the Neumann problem for 2-dimensional wave equation inside of bi-quadratic algebraic curve.
Burskii, Vladimir P., Zhedanov, Alexei S.   +1 more
core   +4 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

On the Boyarsky-Meyers estimate for the solution of the Dirichlet problem for a second-order linear elliptic equation with drift

Современная математика: Фундаментальные направления
We establish the increased integrability of the gradient of the solution to the Dirichlet problem for the Laplace operator with lower terms and prove the unique solvability of this problem.
Yu. A. Alkhutov, G. A. Chechkin
doaj   +1 more source

The full Quantum Spectral Curve for AdS4/CFT3

Journal of High Energy Physics, 2017
The spectrum of planar N $$ \mathcal{N} $$ = 6 superconformal Chern-Simons theory, dual to type IIA superstring theory on AdS4 × CP 3, is accessible at finite coupling using integrability.
Diego Bombardelli, Andrea Cavaglià, Davide Fioravanti, Nikolay Gromov, Roberto Tateo   +4 more
doaj   +1 more source

Non-integrability of measure preserving maps via Lie symmetries [PDF]

, 2015
We consider the problem of characterizing, for certain natural number $m$, the local $\mathcal{C}^m$-non-integrability near elliptic fixed points of smooth planar measure preserving maps. Our criterion relates this non-integrability with the existence of
Cima, Anna, Gasull, Armengol, Mañosa, Víctor   +2 more
core   +6 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

From the Birkhoff-Gustavson normalization to the Bertrand-Darboux integrability condition

, 2000
The Bertrand-Darboux integrability condition for a certain class of perturbed harmonic oscillators is studied from the viewpoint of the Birkhoff-Gustavson(BG)-normalization: By solving an inverse problem of the BG-normalization on computer algebra, it is
Arnold V I, Chekanov N A, Cushman R, Darboux G, Goldstein H, Grosche C, Kummer M, Moser J K, Perelomov A M, Spivak M, Uwano Y, Uwano Y, Uwano Y, Uwano Y, Uwano Y, Whittaker E T, Yamaguchi Y Y, Yoshio Uwano   +17 more
core   +2 more sources

Non-integrability of geodesic flow on certain algebraic surfaces [PDF]

, 2012
This paper addresses an open problem recently posed by V. Kozlov: a rigorous proof of the non-integrability of the geodesic flow on the cubic surface $x y z=1$. We prove this is the case using the Morales-Ramis theorem and Kovacic algorithm.
Acosta-Humánez, Bardin, Churchill, Kovacic, Kozlov, Kozlov, Morales Ruiz, Morales Ruiz, Morales Ruiz, Morales Ruiz, Pujol, Spivak, T.J. Waters, Tsygvintsev, Waters   +14 more
core   +2 more sources