Results 51 to 60 of about 72,758 (294)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

A 4 × 4 Matrix Spectral Problem Involving Four Potentials and Its Combined Integrable Hierarchy

open access: yesAxioms
This paper introduces a specific matrix spectral problem involving four potentials and derives an associated soliton hierarchy using the zero-curvature formulation.
Wen-Xiu Ma, Ya-Dong Zhong
doaj   +1 more source

The one-loop spectral problem of strongly twisted N $$ \mathcal{N} $$ = 4 Super Yang-Mills theory

open access: yesJournal of High Energy Physics, 2019
We investigate the one-loop spectral problem of γ-twisted, planar N $$ \mathcal{N} $$ = 4 Super Yang-Mills theory in the double-scaling limit of infinite, imaginary twist angle and vanishing Yang-Mills coupling constant.
Asger C. Ipsen   +2 more
doaj   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

open access: yesMolecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor   +2 more
wiley   +1 more source

On the integrability of the n-centre problem

open access: yes, 2004
It is known that for $n \geq 3$ centres and positive energies the $n$-centre problem of celestial mechanics leads to a flow with a strange repellor and positive topological entropy.
Knauf, Andreas, Taimanov, Iskander A.
core   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Analytic reducibility of nondegenerate centers: Cherkas systems

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2016
In this paper we study the center problem for polynomial differential systems and we prove that any center of an analytic differential system is analytically reducible.
Jaume Giné, Jaume Llibre
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Explicit solutions of rational integrable differential-difference equations

open access: yesPartial Differential Equations in Applied Mathematics, 2022
The rational integrable differential-difference equations are proposed from a different discrete spectral problem. We proved the Liouville integrability of rational integrable differential-difference equations by deriving its bi-Hamiltonian structures ...
Qiulan Zhao, Muhammad Arham Amin
doaj   +1 more source

Integrability of Lie systems through Riccati equations

open access: yes, 2011
Integrability conditions for Lie systems are related to reduction or transformation processes. We here analyse a geometric method to construct integrability conditions for Riccati equations following these approaches.
Allen J. L.   +37 more
core   +1 more source

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