Results 91 to 100 of about 4,903 (266)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
On dual regime in Yang-Baxter deformed O(2N) sigma models
Journal of High Energy PhysicsIn this paper, we explore a new class of integrable sigma models, which we refer to as the “dual regime” of Yang-Baxter (YB) deformed O(2N) sigma models. This dual regime manifests itself in the conformal perturbation approach.
Alexey Bychkov, Alexey Litvinov
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Pointwise Bounds for Joint Eigenfunctions of Quantum Completely Integrable Systems. [PDF]
Commun Math Phys, 2020 Galkowski J, Toth JA.
europepmc +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Direct linearization approach to discrete integrable systems associated with ℤ𝒩 graded Lax pairs. [PDF]
Proc Math Phys Eng Sci, 2020 Fu W.
europepmc +1 more source
A Global Kam-Theorem: Monodromy in Near-Integrable Perturbations of Spherical Pendulum
Journal of Mathematical and Fundamental Sciences, 2019 The KAM Theory for the persistence of Lagrangean invariant tori in nearly integrable Hamiltonian systems is lobalized to bundles of invariant tori. This leads to globally well-defined conjugations between near-integrable systems and their integrable ...
Henk W. Broer
doaj