Results 111 to 120 of about 9,007,112 (297)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Algebro-Geometric Solutions for a Discrete Integrable Equation

Discrete Dynamics in Nature and Society, 2017
With the assistance of a Lie algebra whose element is a matrix, we introduce a discrete spectral problem. By means of discrete zero curvature equation, we obtain a discrete integrable hierarchy. According to decomposition of the discrete systems, the new
Mengshuang Tao, Huanhe Dong
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Integrable Boundary Flows and the g-function [PDF]

, 2012
This thesis explores renormalisation group flows in integrable quantum field theories with boundaries, as described by the g-function. The main focus is on the g-function in the staircase model, the renormalisation group flow of which passes close to the
WILBOURNE, RUTH,MARGARET, Wilbourne, Ruth Margaret   +1 more
core  

Complete classification of integrability and nonintegrability for spin-1/2 chain with symmetric nearest-neighbor interaction

Physical Review Research
General spin-1/2 chains with symmetric nearest-neighbor interaction are studied. We rigorously prove that all spin models in this class, except for known integrable systems, are nonintegrable in the sense that they possess no nontrivial local conserved ...
Mizuki Sanatani, Yuuya Chiba, Naoto Shiraishi   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Progresses on Some Open Problems Related to Infinitely Many Symmetries

Mathematics
The quest to reveal the physical essence of the infinitely many symmetries and/or conservation laws that are intrinsic to integrable systems has historically posed a significant challenge at the confluence of physics and mathematics.
Senyue Lou
doaj   +1 more source

Thermalization near Integrability in a Dipolar Quantum Newton’s Cradle

Physical Review X, 2018
Isolated quantum many-body systems with integrable dynamics generically do not thermalize when taken far from equilibrium. As one perturbs such systems away from the integrable point, thermalization sets in, but the nature of the crossover from ...
Yijun Tang, Wil Kao, Kuan-Yu Li, Sangwon Seo, Krishnanand Mallayya, Marcos Rigol, Sarang Gopalakrishnan, Benjamin L. Lev   +7 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source