Results 41 to 50 of about 5,324,251 (245)
Formative Dimension of Edward de Bono’s Six Thinking Hats. Pedagogical perspective
Horyzonty WychowaniaRESEARCH OBJECTIVE: The aim of the article is to explore the understanding of the importance of applying Edward de Bono’s six thinking hats in the space of human formation.
Maria Szymańska
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Mapping the dynamics, star-formation rates, and chemical properties of galaxies with integral field spectroscopy [PDF]
, 2005 Major advances in the development of instruments for eight and ten meter class telescopes are revolutionising our understanding of galaxy formation. In particular, Integral Field Spectrographs (which produce a three dimensional {x, y, velocity) map of a ...
Swinbank, Anthony Mark +1 more
core
Design and validation of a graduate profile scale and its relationship with human flourishing
Social Sciences and Humanities OpenUniversities play a key role in forming responsible professionals, a mission reflected in their official statements. To align with this mission, they must define a coherent graduate profile.
Jorge López González +2 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The integral formation of the teaching staff
Avances en Supervisión Educativa, 2006 Marcos Sarasola FUNDACIÓN HORREUM FUNDAZIOA BILBAO Tras analizar el concepto de calidad longitudinalmente (reducción de ratios, recursos, satisfacción de las personas, certificación en calidad...) el autor define centro de calidad como aquél que ...
Marcos Sarasola Bonetti
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Localized boundary-domain integral equation formulation for mixed type problems [PDF]
, 2010 Copyright @ 2010 Walter de Gruyter GmbHSome modified direct localized boundary-domain integral equations (LBDIEs) systems associated with the mixed boundary value problem (BVP) for a scalar “Laplace” PDE with variable coefficient are formulated and ...
Mikhailov, SE +5 more
core +1 more source