Results 61 to 70 of about 207,867 (261)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
AIP Advances, 2020 In this paper, a variational approach is proposed to study the dynamic mechanical response of a single-crystalline Ni–Mn–Ga sample. First, some constitutive assumptions are adopted to describe the material properties of single-crystalline Ni–Mn–Ga alloys.
Jiong Wang, Chengkai Fan
doaj +1 more source
Desarrollo comunitario integral en El Salvador de la posguerra : Centro Bartolomé de las Casas
, 2006 Versión en inglés disponible en la Biblioteca Digital del IDRC: Integral community development in post-war El Salvador : Centro Bartolomé de las ...
Hochachka, Gail
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Integral community development in post-war El Salvador : Centro Bartolomé de las Casas
, 2006 Spanish version available in IDRC Digital Library: Desarrollo comunitario integral en El Salvador de la posguerra : Centro Bartolomé de las CasasThis case study explores the unique response that CBC offers the Salvadoran people.
Hochachka, Gail
core
Developing capacity and community well-being : action research on an integral capacity development approach in the Mapacho River Watershed, Peru [PDF]
, 2009 The project conducted participatory action research with project partners to identity what kinds of methodologies could capture subjective, inter-subjective and objective evidence for monitoring and evaluating capacity development.
Hochachka, Gail, Thomson, Sandra
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
WORLD FINANCIAL STABILITY AND DIVERSIFICATION OF CURRENCIES
Модернизация, инновация, развитие, 2016 Fundamental laws govern all complex flow systems, including natural ecosystems, economic and financial systems. Natural ecosystems are practical examples of sustainability: enduring, vital, adaptive.
Bernard Lietaer +4 more
doaj
, 2017 This article describes the methodology developed for a PhD study to explore the perceptions of Aboriginal Hospital Liaison Officers (AHLOs)and non-Aboriginal social workers about what they understand to be good practice in their work that leads to the ...
Orr, Liz Karen
core