Results 71 to 80 of about 194,925 (268)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Some Carleman-type inequalities in ( p , q ) $(p,q)$ -calculus

Journal of Inequalities and Applications
In this paper, we construct ( p , q ) $\left (p,q\right )$ -type Jessen’s inequality using the properties of convex functions. On this basis, we generalize the classical Carleman integral-type inequality in ( p , q ) $\left (p,q\right )$ -calculus and ...
Jiao Yu, Lin Han
doaj   +1 more source

Hardy-type inequalities in fractional h-discrete calculus

Journal of Inequalities and Applications, 2018
The first power weighted version of Hardy’s inequality can be rewritten as ∫0∞(xα−1∫0x1tαf(t)dt)pdx≤[pp−α−1]p∫0∞fp(x)dx,f≥0,p≥1 ...
Lars-Erik Persson, Ryskul Oinarov, Serikbol Shaimardan   +2 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Problems solving in the integral calculus and the determination of the area under the curve

REMATEC. Revista de Matemática, Ensino e Cultura
In Integral Calculus the classic problem is the determination of the area under the curve, when said region is not expressible in terms of elementary figures.
Juan E. N´apoles Vald´es, Maria Nubia Quevedo   +1 more
doaj   +1 more source

A new view of some operators and their properties in terms of the Non-Newtonian Calculus

Topological Algebra and its Applications, 2017
Differentiation and integration are basic operations of calculus and analysis. Indeed, they are in- finitesimal versions of substraction and addition operations on numbers, respectively.
Ünlüyol Erdal, Salas Seren, Iscan Imdat   +2 more
doaj   +1 more source

On Some Integral Inequalities in Quantum Calculus

Journal of Function Spaces, 2020
The objective of this paper is to establish q-analogue of some well-known inequalities in analysis, namely, Poincaré-type inequalities, Sobolev-type inequalities, and Lyapunov-type inequalities.
Mohamed Jleli, Bessem Samet
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

New Integral Inequalities in Quantum Calculus

International Journal of Analysis and Applications, 2015
In this paper, we study the q-analogue of Klamkin-McLenaghan's and Grueb-Reinboldt's inequalities then we use the Riemann-Liouville fractional q-integral to get some new integral results.
Kamel Brahim, Sabrina Taf, Bochra Nefzi
doaj   +2 more sources

FREDHOLM PROPERTY OF COMPOSITE TWO-DIMENSIONAL INTEGRAL OPERATORS WITH HOMOGENEOUS SINGULAR-TYPE KERNELS IN pL SPACE

Advanced Engineering Research, 2014
The authors have previously studied two - dimensional Fredholm integral operators with homogeneous kernels of fiber - singular type. For this class of operators, the symbolic calculus is built using the theory of biloc al operators by V.
Vladimir Mikhaylovich Deundyak, Elena Anatolyevna Romanenko   +1 more
doaj   +1 more source